Myasthenia Gravis Presenting Initially as Acute Respiratory Failure

Lee, Seung Jun; Hur, Jaehyung; Lee, Tae Won; Ju, Sunmi; Park, Ki-Jong; Cho, Yu Ji; Jeong, Yi Yeong; Lee, Jong Deog; Kim, Ho Cheol

doi:10.4187/respcare.03210

Cited by 8 publications

(10 citation statements)

References 14 publications

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“…Myasthenia gravis (MG) is a relatively rare, but often severe disorder of neuromuscular transmission that causes considerable fatigue 1 2 . MG is initiated by immune reactions in the neuromuscular junction (NMJ) 3 .…”

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confidence: 99%

Clinical application of clustered-AChR for the detection of SNMG

Zhao

Wang

et al. 2015

Sci Rep

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Myasthenia gravis (MG) is an autoantibody-mediated disease of the neuromuscular junction (NMJ). However, accumulating evidence has indicated that MG patients whose serum anti-acetylcholine receptor (AChR) antibodies are not detectable (serumnegative MG; SNMG) in routine assays share similar clinical features with anti-AChR antibody-positive MG patients. We hypothesized that SNMG patients would have low-affinity antibodies to AChRs that would not be detectable using traditional methods but that might be detected by binding to AChR on the cell membrane, particularly if they were clustered at the high density observed at the NMJ. We expressed AChR subunits with the clustering protein rapsyn (an AChR-associated protein at the synapse) in human embryonic kidney (HEK) cells, and we tested the binding of the antibodies using immunofluorescence. With this approach, AChR antibodies to rapsyn-clustered AChR could be detected in the sera from 45.83% (11/24) of SNMG patients, as confirmed with fluorescence-activated cell sorting (FACS). This was the first application in China of cell-based AChR antibody detection. More importantly, this sensitive (and specific) approach could significantly increase the diagnosis rate of SNMG.

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confidence: 99%

Clinical application of clustered-AChR for the detection of SNMG

Zhao

Wang

et al. 2015

Sci Rep

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“…There was no dyspnea, odynophagia, or dysphagia. Myasthenia gravis (MG) is an uncommon autoimmune disease characterized by a cardinal sign of fluctuating muscle weakness, worsening with exertion, and improvement with resting in specific skeletal muscles (Kim et al, 2010;Jayam Trouth et al, 2012;Lee et al, 2015). The incidence of myasthenia gravis is rare only 0.25-2 patients per 100.000 (Wendell and Levine, 2011).…”

Section: Case Reportmentioning

confidence: 99%

A Case Report and Literature Review: Infected Bronchiectasis Induced Myasthenic Crisis Treated Using Noninvasive Ventilator

Kinanti¹,

Puspitorini²,

Illahi³

2022

IJRP

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Introduction: This case report aims to describe an emergency condition of myasthenia gravis in a young adult with a myasthenic crisis due to infected bronchiectasis. The highlight of this case report was the risk factor and the best management of this patient myasthenic crisis episode. Case Description: A 28-years-old male with early-onset generalized myasthenia gravis came with an emergency condition as a myasthenic crisis in the first month of his therapy. This myasthenic crisis condition was concomitant with infected bronchiectasis, which was predicted as the underlying cause. A myasthenic crisis caused by infected bronchiectasis is a rare case that requires extensive airway support and antibiotics. Conclusion: Myasthenic crisis concomitant with bronchiectasis is a rare condition. Both of these conditions could lead to mortality. Extensive and aggressive treatment and guidelines are needed to manage this case. Since bronchiectasis is a permanent condition that tends to occur again in the future, proactive management has to be done to prevent infection and recurrent dyspnea.

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“…Myasthenia gravis (MG) is an organ-specific autoimmune disease characterized by dysfunction of neuromuscular junctions due to antibodies to the acetylcholine receptor (AChR) or, less commonly to muscle-specific tyrosine kinase (MuSK) and is clinically manifested by abnormal fatigue on ordinary activities and fluctuating muscle weakness [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

A rare association: Obesity hypoventilation syndrome with myasthenia gravis and systemic lupus erythematosus, case report

Eldaabossi,

Alrashdan,

Aljanobi

et al. 2023

Respiratory Medicine Case Reports

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Myasthenia Gravis Presenting Initially as Acute Respiratory Failure

Cited by 8 publications

References 14 publications

Clinical application of clustered-AChR for the detection of SNMG

Clinical application of clustered-AChR for the detection of SNMG

A Case Report and Literature Review: Infected Bronchiectasis Induced Myasthenic Crisis Treated Using Noninvasive Ventilator

A rare association: Obesity hypoventilation syndrome with myasthenia gravis and systemic lupus erythematosus, case report

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