MY7 monoclonal antibody for diagnosis of cutaneous T-cell lymphoma

Dréno, B.

doi:10.1001/archderm.126.11.1454

Cited by 6 publications

(3 citation statements)

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“…C onccrning the interest in My7 antigen tCDI3) to help in the diagnosis of early MF, in our series we observed that the expression of this antigen disappeared, mainly when the histological aspect was that of an epidermotropic CTCL, which is in agreement with former studies that showed a disappearance of the expression ofthe My7 antigen in cutaneous lymphomas (MF and Sezary's syndrome) (4,5). However, in our study the expression of this antigen also disappeared in 38 patients with PP with a non-histological aspect of MF.…”

Section: Discussionsupporting

confidence: 91%

“…This study focused on 2 markers: the antigen CD13 and the T-eell reecptor. Indeed, previously, CDI3 (My7) has been identified as an antigen expressed by basal cells in normal skin, whose expression disappeared in epldermotropic cutaneous lymphomas: that is specific to My7 antigen and is not obtained with another CD 13 monoelonal antibody (4,5). This piienomenon is specific to epi derm otropic cutaneous T-eell lymphoma (CTCL).…”

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confidence: 99%

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CD13 and TCR Clone: Markers of Early Mycosis Fungoides

Bernier¹,

Nguyen²,

Quéreux³

et al. 2007

Acta Derm Venereol

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Making a differential diagnosis between early mycosis fungoides and parapsoriasis is often difficult at the clinical and histological level. The aim of this study was to explore markers that could help in this process. A total of 88 patients were included in 2 categories: large plaque parapsoriasis and digitiform parapsoriasis. A histological examination was performed for each patient, and expression of the antigen My7 (CD13), which is lacking in cutaneous T-lymphomas (but not in inflammatory lesions) and rearrangement of the T-cell receptor gene were analysed. A histological aspect of epidermotropic cutaneous T-cell lymphoma was observed in 23.5% of cases of large plaque parapsoriasis and 15% of cases of digitiform parapsoriasis. A disappearance of My7 antigen was noted in the 2 forms of parapsoriasis, more frequently when there was cutaneous T-cell lymphoma histology. A cutaneous clone was observed in 10.3% of cases of large plaque parapsoriasis, but not of digitiform parapsoriasis. For 3 patients, a cutaneous clone and a disappearance of My7 were associated with a non-specific histology. Considering these histological, immunological and molecular biological data, it appears that My7 antigen combined with T-cell clone may help the dermatologist to confirm the diagnosis of early mycosis fungoides. Moreover, further studies will determine whether CD13 is an early prognostic marker of evolution of a parapsoriasis to mycosis fungoides. Finally, these results demonstrate that digitiform parapsoriasis can be an early stage of MF.

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Section: Discussionsupporting

confidence: 91%

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confidence: 99%

CD13 and TCR Clone: Markers of Early Mycosis Fungoides

Bernier¹,

Nguyen²,

Quéreux³

et al. 2007

Acta Derm Venereol

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“…Other immunophenotypic features consistent with a T-cell lymphoblastic malignancy included CD7 positivity [47,481, cytoplasmic staining for CD3 [2], and nonreactivity with B-cell markers and myeloperoxidase. The finding of significant numbers of CD13-positive cells on flow cytometry is also consistent with a mixed AMPD/T-cell lesion, as this marker has been found on activated and malignant T lymphocytes [49,50] as well as myeloid cells. A more likely explanation is that TcR gene rearrangement did not occur, and T-cell development was arrested at the stage of assembly of the TcR-CD3 complex.…”

Section: Discussionsupporting

confidence: 77%

Coexistent T-Cell Lymphoblastic Lymphoma and an Atypical Myeloproliferative Disorder Associated with t(8;13)(p21;q14)

Somers

Slater

Rockman

et al. 1997

Pediatric Pathology & Laboratory Medicine

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This report describes a neoplasm exhibiting both lymphoid and myeloid differentiation associated with an acquired balanced translocation between chromosomes 8 and 13 occurring in a 10-year-old boy. Serial lymph node biopsies revealed the presence of both lymphoblastic lymphoma and an atypical myeloproliferative disorder within the same node. Immunophenotyping was consistent with the presence of an immature T-cell population within the nodal biopsy specimens. Cytogenetic analysis of the bone marrow and lymph node biopsy specimens revealed a unique translocation, t(8;13) (p21;q14). Molecular analysis revealed rearrangement of the immunoglobulin heavy chain gene and germline configuration of the T-cell receptor gene. The patient had a poor response to classical T-cell acute lymphocytic leukemia/lymphoma therapy and was changed to a myeloid leukemia protocol with good response. He underwent bone marrow transplantation but died soon after of overwhelming graft-versus-host disease. We found five similar cases in the literature, suggesting the existence of a subset of mixed lymphoid/myeloid disorders with 8p;13q translocations, in which the clinical picture is dictated by the myeloid element.

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2011

Flow Cytometry of Hematological Malignancies

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MY7 monoclonal antibody for diagnosis of cutaneous T-cell lymphoma

Cited by 6 publications

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CD13 and TCR Clone: Markers of Early Mycosis Fungoides

CD13 and TCR Clone: Markers of Early Mycosis Fungoides

Coexistent T-Cell Lymphoblastic Lymphoma and an Atypical Myeloproliferative Disorder Associated with t(8;13)(p21;q14)

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