My organ is bigger than your organ

Goldsmith, Lowell A.

doi:10.1001/archderm.126.3.301

Cited by 16 publications

(16 citation statements)

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“…One of the largest organs of the body is the skin 1 . It is an organ that separates human body and environment.…”

Section: Skinmentioning

confidence: 99%

A Deep Insight on the Causative Agents Symptoms and Cure for Skin Cancer: A Review

Singh¹,

Saraswat²,

Wal³

et al. 2018

Int. Res. J. Pharm.

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The main objective of this review is to evaluate the current knowledge about the interrelation of skin and nutrient, particularly the influences of nutrients on cutaneous immune responses, the photo protective effects of nutrients and the therapeutic actions of nutrients in skin disorders. The review encompasses some medicinal plants used for the treatment of cancer disease. The plant sources of India likely provide effective anticancer agents. In this article, we have covered the information which is gathered from the plants used recently identified in the cancer treatment. The focused nutrients are carotenoids, vitamins, and polyunsaturated fatty acids.

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“…One of the largest organs of the body is the skin 1 . It is an organ that separates human body and environment.…”

Section: Skinmentioning

confidence: 99%

A Deep Insight on the Causative Agents Symptoms and Cure for Skin Cancer: A Review

Singh¹,

Saraswat²,

Wal³

et al. 2018

Int. Res. J. Pharm.

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“…The skin is the largest single organ of the body, accounting for more than 5.5% of the body mass; in average about 4 kg covering 1.7 m² depending on the height and weight of the individual [1]. The human skin surface is continually exposed to chemicals, mechanical injury, microorganisms, UV-light, temperature variations and water, and the most important function of the skin is to act as a barrier against these exposures.…”

Section: Skin Structurementioning

confidence: 99%

Percutaneous Penetration ‐ Methodological Considerations

Holmgaard

Benfeldt

Nielsen

2014

Basic Clin Pharma Tox

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Studies on percutaneous penetration are needed to assess the hazards after unintended occupational skin exposures to industrial products as well as the efficacy after intended consumer exposure to topically applied medicinal or cosmetic products. During recent decades, a number of methods have been developed to replace methods involving experimental animals. The results obtained from these methods are decided not only by the chemical or product tested, but to a significant degree also by the experimental set-up and decisions made by the investigator during the planning phase. The present MiniReview discusses some of the existing and well-known experimental in vitro and in vivo methods for studies of percutaneous penetration together with some more recent and promising methods. After this, some considerations and recommendations about advantages and limitations of the different methods and their relevance for the prediction of percutaneous penetration are given. Which method to prefer will depend on the product to be tested and the question asked. Regulatory guidelines exist for studies on percutaneous penetration, but researchers as well as regulatory bodies need to pay specific attention to the vehicles and solvents used in donor and sampling fluids so that it reflects in-use conditions as closely as possible. Based on available experimental data, mathematical models have been developed to aid predictions of skin penetration. The authors question the general use of the present mathematical models in hazard assessment, as they seem to ignore outliers among chemicals as well as the heterogeneity of skin barrier properties and skin conditions within the exposed populations. This MiniReview will discuss some of the existing and wellknown experimental in vitro and in vivo models together with some more recent and promising models and give some considerations and recommendations about advantages and limitations of the various models and their relevance for predictions of percutaneous penetration. An overview of the methodologies discussed can be found in table 1.Dermal exposure may be unintentional after environmental or occupational exposure or intentional after the use of topically applied medication or use of cosmetic products. In all cases, the assessment of the potential for percutaneous penetration or temporary deposition within the skin is an essential element in assessing risk as well as efficacy after dermal exposures.Decades of preventive efforts have decreased the inhalational exposures at work places. At the same time, topically applied pharmaceuticals are being used ever more often. Together, this has increased the relative importance of dermal exposures.Knowledge concerning percutaneous penetration and the potential to reach target sites closes the gap from exposure assessment and hazard identification to risk assessment. If a substance is unable to penetrate the stratum corneum (SC) or affect the skin barrier function in any way, then the need for further assessment of risk becomes less evide...

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“…A pele é o maior órgão do corpo humano com uma área de superfície de aproximadamente 1,7 m 2 no indivíduo adulto, o que corresponde a aproximadamente 5,5% da massa corporal (GOLDSMITH, 1990). A pele exerce diversas funções, sendo uma delas a proteção do organismo contra a radiação ultravioleta e contra as agressões mecânicas, químicas e térmicas.…”

Section: Pele -Aspectos Geraisunclassified

Avaliação da eficácia fotoprotetora, penetração cutânea e segurança de formulações cosméticas contendo extratos de chá verde e 'Ginkgo biloba'

Dal'Belo¹

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My organ is bigger than your organ

Cited by 16 publications

References 0 publications

A Deep Insight on the Causative Agents Symptoms and Cure for Skin Cancer: A Review

A Deep Insight on the Causative Agents Symptoms and Cure for Skin Cancer: A Review

Percutaneous Penetration ‐ Methodological Considerations

Avaliação da eficácia fotoprotetora, penetração cutânea e segurança de formulações cosméticas contendo extratos de chá verde e 'Ginkgo biloba'

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