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Cited by 130 publications
(159 citation statements)
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References 40 publications
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“…The a-SMA expression was not found in NOM and LRED. In this study, a-SMA expression was observed in OSCC (Table 3), which was found to be similar to that of a-SMA expression observed by Kellerman et al [24], Seifi et al [27], and Etemad Moghadam et al [26] in OSCC. The results of the present study for HRED (Table 3) were in accordance to Seifi et al [27].…”
Section: Discussionsupporting
confidence: 89%
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“…The a-SMA expression was not found in NOM and LRED. In this study, a-SMA expression was observed in OSCC (Table 3), which was found to be similar to that of a-SMA expression observed by Kellerman et al [24], Seifi et al [27], and Etemad Moghadam et al [26] in OSCC. The results of the present study for HRED (Table 3) were in accordance to Seifi et al [27].…”
Section: Discussionsupporting
confidence: 89%
“…These results are in agreement with Seifi S et al [27] and further strengthen the hypothesis that the higher the number of myofibroblasts, the more invasive the tumor phenotype. This could be due to the fact that myofibroblasts may stimulate tumor progression by stimulating the growth of cancer cells, sustaining blood vessel formation and lymphangiogenesis, attenuating cancer cell death, and stimulating invasion and metastasis by activating proteolysis [24]. In addition, the myofibroblasts may contribute to OSCC invasion through elevation of synthesis of MMP-1, -2, -9 and -13 [41].…”
Section: Discussionmentioning
confidence: 99%
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“…In studies that evaluated the transdifferentiation of fibroblasts to myofibroblasts in OSCC (19,20,21,22) , in two of them, the non-neoplastic epithelium adjacent to invasive SCCs was considered as normal tissue and both studies failed to demonstrate myofibroblasts in the approximal connective tissue,while these investigations showed an increased amount of myofibroblasts in the stroma of SCCs, which is in accordance with the results obtained in this study. None of the two studies had included oral epithelial dysplasia in their samples (19,21).…”
Section: Discussionsupporting
confidence: 88%