volume 8, issue 5, P873-888 2016
DOI: 10.18632/aging.100933
View full text
|
|
Share
Yuan Xing, Wanqing Sun, Yishi Wang, Feng Gao, Heng Ma

Abstract: Insulin protects cardiomyocytes from myocardial ischemia/reperfusion (MI/R) injury through activating Akt. However, phosphatase PHLPP-1 (PH domain leucine-rich repeat protein phosphatase-1) dephosphorylates and inactivates Akt. The balanced competitive interaction of insulin and PHLPP-1 has not been directly examined. In this study, we have identified the effect of mutual inhibition of insulin signaling and PHLPP-1 on the cardioprotective efficiency of Akt in aged heart. Young (3 mon) and aged (20 mon) Sprague…

expand abstract