M G Romanelli, P Mavromara-Nazos, D Spector, B Roizman
Abstract:demonstrated that substitution of sequences of the thymidine kinase (tk) gene, a 13 gene, extending from-16 to +51 with sequences extending from-12 to +104 of the 'Y2 UL49.5 gene in viral recombinant R3820 conferred upon the chimeric gene Xy2 attributes in the context of the viral genome in a productive infection. The UL49.5 gene sequences extending from-179 to +104 contain four DNA binding sites for the major regulatory protein ICP4. Of these sites, two map between nucleotides +20 and +80 within the sequence …
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