Abstract:Lytic transglycosylases function to degrade peptidoglycan strands that comprise the bacterial cell wall. Degradation of peptidoglycan at the septum following cell division is necessary for cell separation, and a deletion ofltgCin Neisseria gonorrhoeae results in growth in clusters of around 6-20 cells rather than as normal diplococci or monococci.N. gonorrhoeaeLtgC is a homolog ofEscherichia coliMltA, and comparison of the two proteins shows that LtgC has an extra domain not found in MltA, referred to as domai… Show more
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