Mutation analysis of transforming growth factor beta type II receptor, Smad2, Smad3 and Smad4 in esophageal squamous cell carcinoma.

Osawa, Hidenobu; Shitara, Yoshinori; Shoji, Hisanori; Mogi, Akira; Kuwano, Hiroyuki; Hagiwara, Kaoru; Takenoshita, Seiichi

doi:10.3892/ijo.17.4.723

Cited by 25 publications

(30 citation statements)

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“…Macroscopic structural mutations of TGF-βRII have been observed in numerous cancer types (29) and it has previously been reported that mutation of the TGF-βRII gene is rarely found in patients with esophageal SCC (30). By contrast, the present study immunohistochemically demonstrated that the expression of TGF-βRII was correlated with the depth of invasion, lymph node metastasis and pathological stage in esophageal SCC.…”

Section: Discussioncontrasting

confidence: 41%

Expression of Smad4, TGF-βRII, and p21waf1 in esophageal squamous cell carcinoma tissue

et al. 2015

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Abstract. Esophageal squamous cell carcinoma (SCC) possesses one of the worst prognoses out of the digestive carcinomas. Several studies have suggested that transforming growth factor β receptor type II (TGF-βRII), Smad family member 4 (Smad4) and p21 wild-type p53-activated factor 1 (p21 waf1 ) are associated with esophageal SCC. The aim of the present study was to evaluate the effect of Smad4, TGF-βRII and p21 waf1 in esophageal squamous cancer tissue and the pathological significance of the effect. An immunohistochemical method was used to evaluate the expression levels of Smad4, TGF-βRII and p21 waf1 in specimens of esophageal SCC lesions obtained from 80 patients. It was found that the expression of Smad4, TGF-βRII and p21 waf1 in histologically-classified grade I esophageal SCC, without invasion or lymph node metastasis, was markedly higher compared with grade III esophageal SCC that had invaded into the deep muscular or serous layer and metastasized to the lymph nodes (P<0.05). Analysis of the expression level of Smad4, TGF-βRII and p21 waf1 , as well as the clinical and pathological characteristics of esophageal SCC, revealed that the three proteins may be associated with the carcinogenesis, biological behavior and prognosis of esophageal SCC, parallel to the pathological stage and cell grade.

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Section: Discussioncontrasting

confidence: 41%

Expression of Smad4, TGF-βRII, and p21waf1 in esophageal squamous cell carcinoma tissue

et al. 2015

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“…Analysis of both primary tumors and cell lines showed components of the TGF-h pathway are generally present and functional in esophageal cancers (13,35). However, as is the case with many epithelial cancers, esophageal cancer cell lines are for the most part resistant to TGF-h-induced growth inhibition (13).…”

Section: Discussionmentioning

confidence: 99%

Inability of Transforming Growth Factor-β to Cause SnoN Degradation Leads to Resistance to Transforming Growth Factor-β–Induced Growth Arrest in Esophageal Cancer Cells

et al. 2005

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“…24 -28 Although macroscopic structural mutations of TGF-␤R-II have been observed in many cancer types, 16,17,31 we have previously reported that mutation of the TGF-␤R-II gene is rarely found in patients with esophageal SCC. 37 Therefore, transcription or translation of mRNA, rather than gene mutation, may be a more common mechanism for the loss of TGF-␤R-II protein expression.…”

Section: Plasma Tgf-␤1 Levels In Patients With Esophageal Carcinomamentioning

confidence: 99%

Reduced expression of transforming growth factor‐β receptors is an unfavorable prognostic factor in human esophageal squamous cell carcinoma

Fukai

Fukuchi

Masuda

et al. 2003

Intl Journal of Cancer

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Mutation analysis of transforming growth factor beta type II receptor, Smad2, Smad3 and Smad4 in esophageal squamous cell carcinoma.

Cited by 25 publications

References 0 publications

Expression of Smad4, TGF-βRII, and p21waf1 in esophageal squamous cell carcinoma tissue

Expression of Smad4, TGF-βRII, and p21waf1 in esophageal squamous cell carcinoma tissue

Inability of Transforming Growth Factor-β to Cause SnoN Degradation Leads to Resistance to Transforming Growth Factor-β–Induced Growth Arrest in Esophageal Cancer Cells

Reduced expression of transforming growth factor‐β receptors is an unfavorable prognostic factor in human esophageal squamous cell carcinoma

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