Mutagenicity study of nine monoalkyl phthalates and a dialkyl phthalate using Salmonella typhimurium and Escherichia coli

Carcinogenic potential of phthalic acid esters and related compounds: structure-activity relationships.

“…The PAEs and the 2-ethylhexyl-containing compounds compared in this communication have been found to lack mutagenic activity in Salmonella typhimurium testing strains (14,15,(29)(30)(31); also E. Zeiger, National Toxicology Program, personal communication). While some chromosomal changes have been reported to be induced by DEHP or the monoeasters mono(2-ethylhexyl) phthalate or mono(2-ethylhexyl) adipate in vitro (32), such effects have not been confirmed in vivo.…”

Carcinogenic potential of phthalic acid esters and related compounds: structure-activity relationships.

“…The PAEs and the 2-ethylhexyl-containing compounds compared in this communication have been found to lack mutagenic activity in Salmonella typhimurium testing strains (14,15,(29)(30)(31); also E. Zeiger, National Toxicology Program, personal communication). While some chromosomal changes have been reported to be induced by DEHP or the monoeasters mono(2-ethylhexyl) phthalate or mono(2-ethylhexyl) adipate in vitro (32), such effects have not been confirmed in vivo.…”

DEHP: Genotoxicity and potential carcinogenic mechanisms—A review

“…Under cytotoxic conditions, increased numbers of revertants from DNA reactivity of a test substance would be countered by decreased numbers of revertants due to toxicity. This situation is illustrated by the results of Yoshikawa et al [211] who noted that cytotoxicity affects mutation results in the Ames assay with greater decreases in revertants due to cytotoxicity for MEHP than DEHP.…”

Sonolytic Degradation of Phthalic Acid Esters in Aqueous Solutions. Acceleration of Hydrolysis by Sonochemical Action

“…The concentration of monoethyl phthalate (MEP), which was regarded as the hydrolysis product of DEP, was approximately 3.3 times higher at pH 12 than at pH 7. It was reported that the monoalkyl phthalate including MEP during the test using bacterial indicators was not mutagenic . As sonolysis progresses, the produced MEP began to slowly decompose during the sonolysis at pH 12.…”

“…It was reported that the monoalkyl phthalate including MEP during the test using bacterial indicators was not mutagenic. 19 As sonolysis progresses, the produced MEP began to slowly decompose during the sonolysis at pH 12.…”

Carcinogenic potential of phthalic acid esters and related compounds: structure-activity relationships.

“…The PAEs and the 2-ethylhexyl-containing compounds compared in this communication have been found to lack mutagenic activity in Salmonella typhimurium testing strains (14,15,(29)(30)(31); also E. Zeiger, National Toxicology Program, personal communication). While some chromosomal changes have been reported to be induced by DEHP or the monoeasters mono(2-ethylhexyl) phthalate or mono(2-ethylhexyl) adipate in vitro (32), such effects have not been confirmed in vivo.…”

DEHP: Genotoxicity and potential carcinogenic mechanisms—A review

“…Under cytotoxic conditions, increased numbers of revertants from DNA reactivity of a test substance would be countered by decreased numbers of revertants due to toxicity. This situation is illustrated by the results of Yoshikawa et al [211] who noted that cytotoxicity affects mutation results in the Ames assay with greater decreases in revertants due to cytotoxicity for MEHP than DEHP.…”

Sonolytic Degradation of Phthalic Acid Esters in Aqueous Solutions. Acceleration of Hydrolysis by Sonochemical Action

“…The concentration of monoethyl phthalate (MEP), which was regarded as the hydrolysis product of DEP, was approximately 3.3 times higher at pH 12 than at pH 7. It was reported that the monoalkyl phthalate including MEP during the test using bacterial indicators was not mutagenic . As sonolysis progresses, the produced MEP began to slowly decompose during the sonolysis at pH 12.…”

“…It was reported that the monoalkyl phthalate including MEP during the test using bacterial indicators was not mutagenic. 19 As sonolysis progresses, the produced MEP began to slowly decompose during the sonolysis at pH 12.…”

Carcinogenic potential of phthalic acid esters and related compounds: structure-activity relationships.

“…The PAEs and the 2-ethylhexyl-containing compounds compared in this communication have been found to lack mutagenic activity in Salmonella typhimurium testing strains (14,15,(29)(30)(31); also E. Zeiger, National Toxicology Program, personal communication). While some chromosomal changes have been reported to be induced by DEHP or the monoeasters mono(2-ethylhexyl) phthalate or mono(2-ethylhexyl) adipate in vitro (32), such effects have not been confirmed in vivo.…”

DEHP: Genotoxicity and potential carcinogenic mechanisms—A review

“…Under cytotoxic conditions, increased numbers of revertants from DNA reactivity of a test substance would be countered by decreased numbers of revertants due to toxicity. This situation is illustrated by the results of Yoshikawa et al [211] who noted that cytotoxicity affects mutation results in the Ames assay with greater decreases in revertants due to cytotoxicity for MEHP than DEHP.…”

Sonolytic Degradation of Phthalic Acid Esters in Aqueous Solutions. Acceleration of Hydrolysis by Sonochemical Action

“…The concentration of monoethyl phthalate (MEP), which was regarded as the hydrolysis product of DEP, was approximately 3.3 times higher at pH 12 than at pH 7. It was reported that the monoalkyl phthalate including MEP during the test using bacterial indicators was not mutagenic . As sonolysis progresses, the produced MEP began to slowly decompose during the sonolysis at pH 12.…”

“…It was reported that the monoalkyl phthalate including MEP during the test using bacterial indicators was not mutagenic. 19 As sonolysis progresses, the produced MEP began to slowly decompose during the sonolysis at pH 12.…”