Mussel-inspired poly(L-DOPA)-templated mineralization for calcium phosphate-assembled intracellular nanocarriers

Nam, Hye Young; Min, Kyung Hyun; Kim, Da Eun; Choi, Jeong Ryul; Lee, Hong Jae; Lee, Sang Cheon

doi:10.1016/j.colsurfb.2017.05.077

Cited by 20 publications

(9 citation statements)

References 45 publications

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“…The pathway of melanin biosynthesis involves the enzymatic oxidation of dopamine (3,4-dihydroxyphenethylamine) or tyrosine to dopachrome, followed by alteration to 5,6-dihydroxyindole (DHI) or 5,6-dihydroxy-indole-2-carboxylic acid (DHICA), which proceeds further through oxidative polymerization to melanin [ 15 ]. Synthetic melanin-like nanoparticles are generally obtained by chemical or enzymatic oxidation of dopamine (3,4-dihydroxyphenethylamine) or L-DOPA (L-3,4-dihydroxyphenylalanine) [ 16 , 17 , 18 ].…”

Section: Resultsmentioning

confidence: 99%

T1-Positive Mn2+-Doped Multi-Stimuli Responsive poly(L-DOPA) Nanoparticles for Photothermal and Photodynamic Combination Cancer Therapy

et al. 2020

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In this study, we designed near-infrared (NIR)-responsive Mn2+-doped melanin-like poly(L-DOPA) nanoparticles (MNPs), which act as multifunctional nano-platforms for cancer therapy. MNPs, exhibited favorable π-π stacking, drug loading, dual stimuli (NIR and glutathione) responsive drug release, photothermal and photodynamic therapeutic activities, and T1-positive contrast for magnetic resonance imaging (MRI). First, MNPs were fabricated via KMnO4 oxidation, where the embedded Mn2+ acted as a T1-weighted contrast agent. MNPs were then modified using a photosensitizer, Pheophorbide A, via a reducible disulfide linker for glutathione-responsive intracellular release, and then loaded with doxorubicin through π-π stacking and hydrogen bonding. The therapeutic potential of MNPs was further explored via targeted design. MNPs were conjugated with folic acid (FA) and loaded with SN38, thereby demonstrating their ability to bind to different anti-cancer drugs and their potential as a versatile platform, integrating targeted cancer therapy and MRI-guided photothermal and chemotherapeutic therapy. The multimodal therapeutic functions of MNPs were investigated in terms of T1-MR contrast phantom study, photothermal and photodynamic activity, stimuli-responsive drug release, enhanced cellular uptake, and in vivo tumor ablation studies.

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Section: Resultsmentioning

confidence: 99%

T1-Positive Mn2+-Doped Multi-Stimuli Responsive poly(L-DOPA) Nanoparticles for Photothermal and Photodynamic Combination Cancer Therapy

et al. 2020

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“…Biomimetic calcium phosphate materials have attracted considerable attention due to their pH responsiveness, biodegradability, and lack of cytotoxicity. For example, CaP has been fabricated using poly(3,4-dihydroxy-l-phenylalanine) (PDOPA) and poly(ethylene glycol) (PEG) as templates by a biomimetic process inspired by mussels (Nam et al, 2017). Doxorubicin (DOX), a widely used cancer drug, was effectively loaded within the CaP nanoparticles up to a weight ratio of 10.8% due to its interaction with CaP.…”

Section: Cell Deliverymentioning

confidence: 99%

Novel nanomaterial–organism hybrids with biomedical potential

Cui

Wang

et al. 2021

WIREs Nanomed Nanobiotechnol

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Instinctive hierarchically biomineralized structures of various organisms, such as eggs, algae, and magnetotactic bacteria, afford extra protection and distinct performance, which endow fragile organisms with a tenacious ability to adapt and survive. However, spontaneous formation of hybrid materials is difficult for most organisms in nature. Rapid development of chemistry and materials science successfully obtained the combinations of organisms with nanomaterials by biomimetic mineralization thus demonstrating the reproduction of the structures and functions and generation of novel functions that organisms do not possess. The rational design of biomaterial–organism hybridization can control biological recognition, interactions, and metabolism of the organisms. Thus, nanomaterial–organism hybrids represent a next generation of organism engineering with great potential biomedical applications. This review summarizes recent advances in material‐directed organism engineering and is mainly focused on biomimetic mineralization technologies and their outstanding biomedical applications. Three representative types of biomimetic mineralization are systematically introduced, including external mineralization, internal mineralization, and genetic engineering mineralization. The methods involving hybridization of nanomaterials and organisms based on biomimetic mineralization strategies are described. These strategies resulted in applications of various nanomaterial–organism hybrids with multiplex functions in cell engineering, cancer treatment, and vaccine improvement. Unlike classical biological approaches, this material‐based bioregulation is universal, effective, and inexpensive. In particular, instead of traditional medical solutions, the integration of nanomaterials and organisms may exploit novel strategies to solve current biomedical problems. This article is categorized under: Implantable Materials and Surgical Technologies > Nanomaterials and Implants Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease

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“…This type of adhesion to both organic and inorganic compounds is highly interesting for the development of bone adhesives since bone is also a mixture of organic and inorganic components. The carboxylic acid group and the hydroxyl groups from the catechol of DOPA form ionic bonding with calcium, which seems to indicate that DOPA can bind to bone tissue . The authors claimed that DOPA promoted the process of bone formation as evidenced by the in vivo maturation of new bones with a similar bone density to the normal bone and the in vitro osteogenic differentiation of osteoblast cells …”

Section: Bone Adhesives Made From Natural Polymersmentioning

confidence: 99%

Bone‐Adhesive Materials: Clinical Requirements, Mechanisms of Action, and Future Perspective

Sanchez-Fernandez

Hammoudeh

Lanao

et al. 2019

Adv Materials Inter

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Each year, millions of people suffer from complex bone fractures which require proper external or internal fixation. This fixation is usually achieved by means of devices such as plates, pins, and screws. These traditional fixation strategies are associated with severe drawbacks, which have prompted research and development of a variety of bone‐adhesive biomaterials as alternative. However, a clinically applicable bone‐adhesive biomaterial—in the form of a bone‐glue or bone‐adhesive membrane—that meets all requirements has not yet been identified. This perspective article discusses the current state of the art of bone‐adhesive materials with a particular focus on their clinical requirements, mechanisms of action, and future perspective. To develop adhesive biomaterials with specific affinity to bone tissue, a more rational design should be implemented. This perspective article is intended as a starting point and inspiration for future research and development of suitable bone‐adhesive materials.

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Mussel-inspired poly(L-DOPA)-templated mineralization for calcium phosphate-assembled intracellular nanocarriers

Cited by 20 publications

References 45 publications

T1-Positive Mn2+-Doped Multi-Stimuli Responsive poly(L-DOPA) Nanoparticles for Photothermal and Photodynamic Combination Cancer Therapy

T1-Positive Mn2+-Doped Multi-Stimuli Responsive poly(L-DOPA) Nanoparticles for Photothermal and Photodynamic Combination Cancer Therapy

Novel nanomaterial–organism hybrids with biomedical potential

Bone‐Adhesive Materials: Clinical Requirements, Mechanisms of Action, and Future Perspective

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