Musculoskeletal Applications of Platelet-Rich Plasma: Fad or Future?

Lee, Kenneth S.; Wilson, J. B.; Rabago, David; Baer, Geoffrey S.; Jacobson, Jon A.; Borrero, Camilo

doi:10.2214/ajr.10.5975

Cited by 85 publications

(76 citation statements)

References 65 publications

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“…PRP is a concentrated source of autologous platelets and thus may be used as an autologous fibrin glue system. In humans, PRP has been investigated for several types of treatments, including nerve injury, tendonitis, myocardial injury, orthopedics and dentistry (Hildner et al 2011;Lee et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Biomimetic tubular nanofiber mesh and platelet rich plasma-mediated delivery of BMP-7 for large bone defect regeneration

et al. 2012

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There is a growing need for successful bone tissue engineering strategies and advanced biomaterials that mimic the structure and function of native tissues carry great promise. Successful bone repair approaches may include an osteoconductive scaffold, osteoinductive growth factors, cells with an osteogenic potential and capacity for graft vascularisation. To increase osteoinductivity of biomaterials, the local combination and delivery of growth factors has been developed. In the present study we investigated the osteogenic effects of calcium phosphate (CaP)-coated nanofiber mesh tube-mediated delivery of BMP-7 from a PRP matrix for the regeneration of critical sized segmental bone defects in a small animal model. Bilateral full-thickness diaphyseal segmental defects were created in twelve male Lewis rats and nanofiber mesh tubes were placed around the defect. Defects received either treatment with a CaP-coated nanofiber mesh tube (n = 6), an un-coated nanofiber mesh tube (n=6) a CaP-coated nanofiber mesh tube with PRP (n=6) or a CaP-coated nanofiber mesh tube in combination with 5 μg BMP-7 and PRP (n = 6). After 12 weeks, bone volume and biomechanical properties were evaluated using radiography, microCT, biomechanical testing and histology. The results demonstrated significantly higher biomechanical properties and bone volume for the BMP group compared to the control groups. These results were supported by the histological evaluations, where BMP group showed the highest rate of bone regeneration within the defect. In conclusion, BMP-7 delivery via PRP enhanced functional bone defect regeneration, and together these data support the use of BMP-7 in the treatment of critical sized defects.

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Section: Introductionmentioning

confidence: 99%

Biomimetic tubular nanofiber mesh and platelet rich plasma-mediated delivery of BMP-7 for large bone defect regeneration

et al. 2012

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“…The third disadvantage is the continued use of bovine thrombin for clotting the liquid preparation of PRP. [29][30][31] Prgf: To overcome these drawbacks, Anitua developed plasma rich in growth factors (PRGF) by modifying the procedure of PRP preparation. [32] It simplified the preparation protocol and replaced animalderived thrombin with calcium for clotting.…”

Section: Platelet Rich Plasma (Prp) and Platelet Rich In Growth Factomentioning

confidence: 99%

Bioactive Platelet Aggregates: Prp, Prgf, Prf, Cgf And Sticky Bone

Upadhyaya¹,

Arora²,

Goyal³

2017

IOSR JDMS

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“…It contains more than 30 bioactive components [Mishra, 2010;Pallua et al, 2010;Soomekh, 2010] that are capable of promoting the healing of various tissues. Because of its autogenous origin, easy preparation, and an excellent safety profile, PRP therapy has risen in popularity for use in musculoskeletal tissue healing [Alsousou et al, 2009;Borrione et al, 2010;Lee et al, 2011;Nguyen et al, 2011;Soomekh, 2011]; however, the clinical results of PRP therapy are inconclusive and its mechanisms of action are largely unknown [Andia et al, 2011;Lee et al, 2011;Mishra et al, 2012]. There are numerous complex molecular and cellular variations in PRP due in part to differences in the preparation protocols, the use of anticoagulants, the inclusion of leukocytes, and the use of platelet activators, each of which may lead to variations in its biological effects [Weibrich et al, 2002;Kalen et al, 2008;Dohan Ehrenfest et al, 2009;Lei et al, 2009;Mazzucco et al, 2009].…”

Section: Various Approaches Can Be Used To Improve Muscle Regenerationmentioning

confidence: 99%

Muscle Injuries and Repair: What's New on the Horizon!

Huard

Lü

et al. 2016

Cells Tissues Organs

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Although we recognize the many advantages of improved musculoskeletal health, we also note that our ability to sustain this health and to maintain quality of life in an aging population is currently deficient. However, global efforts have produced numerous advances in tissue engineering and regenerative medicine that will collectively serve to fill this deficiency in the near future. The purpose of this review is to highlight our current knowledge, to outline our recent advances, and to discuss the evolving paradigms in skeletal muscle injury and repair.

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Musculoskeletal Applications of Platelet-Rich Plasma: Fad or Future?

Abstract: Any promising minimally invasive therapy such as PRP deserves further investigation to avoid surgery. Diagnostic imaging outcome assessments, including ultrasound-guided needle precision, should be included in future investigations.

Cited by 85 publications

References 65 publications

Biomimetic tubular nanofiber mesh and platelet rich plasma-mediated delivery of BMP-7 for large bone defect regeneration

Biomimetic tubular nanofiber mesh and platelet rich plasma-mediated delivery of BMP-7 for large bone defect regeneration

Bioactive Platelet Aggregates: Prp, Prgf, Prf, Cgf And Sticky Bone

Muscle Injuries and Repair: What's New on the Horizon!

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