Muscovy duck retinoic acid-induced gene I (MdRIG-I) functions in innate immunity against H9N2 avian influenza viruses (AIV) infections

Cheng, Yuqiang; Huang, Qingqing; Ji, Wenhui; Du, Bin; Fu, Qiang; An, Huiting; Li, Jing; Wang, Hengan; Yan, Yaxian; Ding, Chan; Sun, Jianhe

doi:10.1016/j.vetimm.2014.12.009

Cited by 34 publications

(23 citation statements)

References 42 publications

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“…A comparison of tissue expression of RLR pathway components between chickens and ducks illustrates the readiness of these tissues to respond to pathogens (Figure 2A). In Muscovy ducks, RIG-I is most highly expressed in the trachea and digestive tissues (Cheng et al, 2015a). Chickens appear to have lost RIG-I (Barber et al, 2010).…”

Section: Rig-imentioning

confidence: 99%

“…In these studies, RIG-I is upregulated much more during HPAI infection than LPAI infection. In Muscovy ducks RIG-I mRNA expression peaked at 2 DPI in brain and spleen, while expression was highest 1 DPI in the lung and bursa (Cheng et al, 2015a). Muscovy ducks are more susceptible to influenza infection than mallard ducks (Phuong do et al, 2011), and this slight delay in RIG-I upregulation may contribute.…”

Section: Rig-imentioning

confidence: 99%

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Pattern Recognition Receptor Signaling and Innate Responses to Influenza A Viruses in the Mallard Duck, Compared to Humans and Chickens

Campbell

Magor

2020

Front. Cell. Infect. Microbiol.

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Mallard ducks are a natural host and reservoir of avian Influenza A viruses. While most influenza strains can replicate in mallards, the virus typically does not cause substantial disease in this host. Mallards are often resistant to disease caused by highly pathogenic avian influenza viruses, while the same strains can cause severe infection in humans, chickens, and even other species of ducks, resulting in systemic spread of the virus and even death. The differences in influenza detection and antiviral effectors responsible for limiting damage in the mallards are largely unknown. Domestic mallards have an early and robust innate response to infection that seems to limit replication and clear highly pathogenic strains. The regulation and timing of the response to influenza also seems to circumvent damage done by a prolonged or dysregulated immune response. Rapid initiation of innate immune responses depends on viral recognition by pattern recognition receptors (PRRs) expressed in tissues where the virus replicates. RIG-like receptors (RLRs), Toll-like receptors (TLRs), and Nod-like receptors (NLRs) are all important influenza sensors in mammals during infection. Ducks utilize many of the same PRRs to detect influenza, namely RIG-I, TLR7, and TLR3 and their downstream adaptors. Ducks also express many of the same signal transduction proteins including TBK1, TRIF, and TRAF3. Some antiviral effectors expressed downstream of these signaling pathways inhibit influenza replication in ducks. In this review, we summarize the recent advances in our understanding of influenza recognition and response through duck PRRs and their adaptors. We compare basal tissue expression and regulation of these signaling components in birds, to better understand what contributes to influenza resistance in the duck.

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Section: Rig-imentioning

confidence: 99%

Section: Rig-imentioning

confidence: 99%

Pattern Recognition Receptor Signaling and Innate Responses to Influenza A Viruses in the Mallard Duck, Compared to Humans and Chickens

Campbell

Magor

2020

Front. Cell. Infect. Microbiol.

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“…These results indicate that the full length of rNOD1 may play an essential role in inducing the production of cytokines and defensins, which display diverse antimicrobial activities against various microorganisms, including Gram-positive and Gram-negative bacteria, fungi, and viruses. By contrast, previous studies have suggested that, because the C-terminal regulatory domain of Muscovy duck (Md) MDA5 and MdRIG-I can self-repress, overexpression of the CARD of MdMDA5 and MdRIG-I can activate signaling pathways more strongly than overexpression of the full length protein ( 46 , 47 ). The activation of NOD1 results in oligomerization mediated by the nucleotide-binding NACHT domain to create a platform for the activation of downstream signaling molecules ( 44 ).…”

Section: Discussionmentioning

confidence: 79%

Characterization of Rabbit Nucleotide-Binding Oligomerization Domain 1 (NOD1) and the Role of NOD1 Signaling Pathway during Bacterial Infection

Guo

Hao

et al. 2017

Front. Immunol.

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Nucleotide-binding oligomerization domain 1 (NOD1) is the most prominent of all NOD-like receptors, which in the mammalian innate immune system, serve as intracellular receptors for pathogens and endogenous molecules during tissue injury. From rabbit kidney cells, we cloned rabbit NOD1 (rNOD1) and identified an N-terminal caspase activation and recruitment domain, a central NACHT domain, and C-terminal leucine-rich repeat domains. rNOD1 was expressed in all tested tissues; infection with Escherichia coli induced significantly higher expression in the spleen, liver, and kidney compared to other tissues. The overexpression of rNOD1 induced the expression of proinflammatory cytokines Il1b, Il6, Il8, Ifn-γ, and Tnf and defensins, including Defb124, Defb125, Defb128, Defb135, and Np5 via activation of the nuclear factor (NF)-κB pathway. Overexpression of rNOD1 inhibited the growth of E. coli, whereas knockdown of rNOD1 or inhibition of the NF-κB pathway promoted the growth of E. coli. rNOD1 colocalized with LC3, upregulated autophagy pathway protein LC3-II, and increased autolysosome formation in RK-13 cells infected with E. coli. In summary, our results explain the primary signaling pathway and antibacterial ability of rNOD1, as well as the induction of autophagy that it mediates. Such findings suggest that NOD1 could contribute to therapeutic strategies such as targets of new vaccine adjuvants or drugs.

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“…RIG 1 plays a crucial role in the immune response against Newcastle disease by up-regulation of IFN-β and mRNA levels of IRF 3 and IFIT1, which has been proven in geese [81]. In cases of low pathogenic avian influenza, ducks can up-regulate RIG 1 and limit virus replication in lungs by robust up-regulation of IFN-β [82,83]. In chickens, the role of RIG 1 is taken over by MDA5, but MDA5 probably does not play a decisive role during the immune response to influenza virus.…”

Section: Retinoic-acid-inducible Gene I-like Receptorsmentioning

confidence: 99%

Immunomodulation of Avian Dendritic Cells under the Induction of Prebiotics

Zmrhal

Sláma

2020

Animals

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Although the immunomodulatory properties of prebiotics were demonstrated many years ago in poultry, not all mechanisms of action are yet clear. Dendritic cells (DCs) are the main antigen-presenting cells orchestrating the immune response in the chicken gastrointestinal tract, and they are the first line of defense in the immune response. Despite the crucial role of DCs in prebiotic immunomodulatory properties, information is lacking about interaction between prebiotics and DCs in an avian model. Mannan-oligosaccharides, β-glucans, fructooligosaccharides, and chitosan-oligosaccharides are the main groups of prebiotics having immunomodulatory properties. Because pathogen-associated molecular patterns on these prebiotics are recognized by many receptors of DCs, prebiotics can mimic activation of DCs by pathogens. Short-chain fatty acids are products of prebiotic fermentation by microbiota, and their anti-inflammatory properties have also been demonstrated in DCs. This review summarizes current knowledge about avian DCs in the gastrointestinal tract, and for the first-time, their role in the immunomodulatory properties of prebiotics within an avian model.

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Muscovy duck retinoic acid-induced gene I (MdRIG-I) functions in innate immunity against H9N2 avian influenza viruses (AIV) infections

Cited by 34 publications

References 42 publications

Pattern Recognition Receptor Signaling and Innate Responses to Influenza A Viruses in the Mallard Duck, Compared to Humans and Chickens

Pattern Recognition Receptor Signaling and Innate Responses to Influenza A Viruses in the Mallard Duck, Compared to Humans and Chickens

Characterization of Rabbit Nucleotide-Binding Oligomerization Domain 1 (NOD1) and the Role of NOD1 Signaling Pathway during Bacterial Infection

Immunomodulation of Avian Dendritic Cells under the Induction of Prebiotics

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