Muscle relaxants for pain management in rheumatoid arthritis

Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype

“…Our present results and previous pain studies employing subtype-selective BDZ site agonists in rodents 5 20 26 27 28 29 contrast with the lack of a clear analgesic or antihyperalgesic action of classical BDZs in human patients 30 31 . Apart from species differences and differences between disease models and actual disease in human patients, we found one possible explanation particularly worth studying.…”

Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype

“…Our present results and previous pain studies employing subtype-selective BDZ site agonists in rodents 5 20 26 27 28 29 contrast with the lack of a clear analgesic or antihyperalgesic action of classical BDZs in human patients 30 31 . Apart from species differences and differences between disease models and actual disease in human patients, we found one possible explanation particularly worth studying.…”

Evaluation of anti-mutated citrullinated vimentin antibodies, anti-cyclic citrullinated peptide antibodies in patients with rheumatoid arthritis in comparison with other rheumatic diseases; a nephrology point of view

“…This might be a reason that anti-MCV has been introduced as a new biomarker for diagnosis of ankylosing spondylitis (62). Positive anti-MCV was also reported in SLE, Sjögren's syndrome, psoriatic arthritis, Epstein-Barr virus and hepatitis C virus infected patients (56,59). Because of low proportion of non-RA controls in our study, we obtained these results.…”

“…In addition, this finding has been confirmed by Syversen et al, who reported more advanced joint damage in patients with anti-MCV positivity (57). In most of researches, the sensitivity of anti-MCV was somehow higher than anti-CCP, but anti-CCP was more specific (34,56,58,59). The similar results have been demonstrated in another studies while investigators found that in RF negative patients, the sensitivity of anti-MCV is high (43.8% versus 30%) (56).…”

Effects of Koumine on Adjuvant- and Collagen-Induced Arthritis in Rats

“…Pain management, a priority in the medical care of RA patients, remains a major challenge despite major advances in treatment strategies over the past few decades . In the current study, koumine exhibited a dose-dependent analgesic activity on MWT in both AIA and CIA models.…”

Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype

“…Our present results and previous pain studies employing subtype-selective BDZ site agonists in rodents 5 20 26 27 28 29 contrast with the lack of a clear analgesic or antihyperalgesic action of classical BDZs in human patients 30 31 . Apart from species differences and differences between disease models and actual disease in human patients, we found one possible explanation particularly worth studying.…”

Evaluation of anti-mutated citrullinated vimentin antibodies, anti-cyclic citrullinated peptide antibodies in patients with rheumatoid arthritis in comparison with other rheumatic diseases; a nephrology point of view

“…This might be a reason that anti-MCV has been introduced as a new biomarker for diagnosis of ankylosing spondylitis (62). Positive anti-MCV was also reported in SLE, Sjögren's syndrome, psoriatic arthritis, Epstein-Barr virus and hepatitis C virus infected patients (56,59). Because of low proportion of non-RA controls in our study, we obtained these results.…”

“…In addition, this finding has been confirmed by Syversen et al, who reported more advanced joint damage in patients with anti-MCV positivity (57). In most of researches, the sensitivity of anti-MCV was somehow higher than anti-CCP, but anti-CCP was more specific (34,56,58,59). The similar results have been demonstrated in another studies while investigators found that in RF negative patients, the sensitivity of anti-MCV is high (43.8% versus 30%) (56).…”

Effects of Koumine on Adjuvant- and Collagen-Induced Arthritis in Rats

“…Pain management, a priority in the medical care of RA patients, remains a major challenge despite major advances in treatment strategies over the past few decades . In the current study, koumine exhibited a dose-dependent analgesic activity on MWT in both AIA and CIA models.…”

Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype

“…Our present results and previous pain studies employing subtype-selective BDZ site agonists in rodents 5 20 26 27 28 29 contrast with the lack of a clear analgesic or antihyperalgesic action of classical BDZs in human patients 30 31 . Apart from species differences and differences between disease models and actual disease in human patients, we found one possible explanation particularly worth studying.…”

Evaluation of anti-mutated citrullinated vimentin antibodies, anti-cyclic citrullinated peptide antibodies in patients with rheumatoid arthritis in comparison with other rheumatic diseases; a nephrology point of view

“…This might be a reason that anti-MCV has been introduced as a new biomarker for diagnosis of ankylosing spondylitis (62). Positive anti-MCV was also reported in SLE, Sjögren's syndrome, psoriatic arthritis, Epstein-Barr virus and hepatitis C virus infected patients (56,59). Because of low proportion of non-RA controls in our study, we obtained these results.…”

“…In addition, this finding has been confirmed by Syversen et al, who reported more advanced joint damage in patients with anti-MCV positivity (57). In most of researches, the sensitivity of anti-MCV was somehow higher than anti-CCP, but anti-CCP was more specific (34,56,58,59). The similar results have been demonstrated in another studies while investigators found that in RF negative patients, the sensitivity of anti-MCV is high (43.8% versus 30%) (56).…”

Effects of Koumine on Adjuvant- and Collagen-Induced Arthritis in Rats

“…Pain management, a priority in the medical care of RA patients, remains a major challenge despite major advances in treatment strategies over the past few decades . In the current study, koumine exhibited a dose-dependent analgesic activity on MWT in both AIA and CIA models.…”