2015
DOI: 10.1002/jor.22786
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Abstract: Chronic rotator cuff (RC) tears affect a large portion of the population and result in substantial upper extremity impairment, shoulder weakness, pain and limited range of motion. Regardless of surgical or conservative treatment, persistent atrophic muscle changes limit functional restoration and may contribute to surgical failure. We hypothesized that deficits in the skeletal muscle progenitor (SMP) cell pool could contribute to poor muscle recovery following tendon repair. Biopsies were obtained from patient… Show more

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Cited by 29 publications
(45 citation statements)
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References 33 publications
(74 reference statements)
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“…These results suggest that satellite cells in disused muscles could be a therapeutic target for myogenic differentiation although the fatty infiltration of the muscle was severe. A previous study reported that a comparison of muscle precursors from bursitis and partial-and full-thickness RCT (Meyer et al 2015) found no differences in muscle regeneration capacity, which was consistent with our results. In this study, arthroscopic surgery enabled us to accurately compare the nature of disused and intact muscles simultaneously in the same patients.…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…These results suggest that satellite cells in disused muscles could be a therapeutic target for myogenic differentiation although the fatty infiltration of the muscle was severe. A previous study reported that a comparison of muscle precursors from bursitis and partial-and full-thickness RCT (Meyer et al 2015) found no differences in muscle regeneration capacity, which was consistent with our results. In this study, arthroscopic surgery enabled us to accurately compare the nature of disused and intact muscles simultaneously in the same patients.…”
Section: Discussionsupporting
confidence: 93%
“…The physical load of muscles rapidly induces satellite cell activation and proliferation for damage repair and muscle regeneration (Zammit et al 2006). It remains unclear whether human satellite cells maintain muscle regeneration capacity in disused muscles, regardless of RCT severity (Meyer et al 2015).…”
Section: Introductionmentioning
confidence: 99%
“…Samples with adequate numbers of surviving cells were then culture expanded in growth medium, changing the medium every 2-3 days. Skeletal muscle progenitor (SMP) cells were isolated, as previously described [25]. In brief, muscle biopsies were digested in a solution containing collagenase type I and dispase II, mechanically dissociated, and filtered to yield a suspension of mononuclear cells.…”
Section: Stem Cell and Progenitor Isolationmentioning
confidence: 99%
“…In recent years, numerous studies have shown large failure rates, causing concern about supraspinatus strangulation contractures from adhesion by fatty infiltration. Chen et al [30][31][32] investigated the effects of chitosan on Achilles tendon injury in rats 8 weeks after surgery. Gliding excursion and the content of collagen fibers were used to evaluate the effects of surgery.…”
Section: ■ Discussionmentioning
confidence: 99%