Muscle pain as an indicator of vitamin D deficiency in an urban Australian Aboriginal population

Benson, Jill; Wilson, Anne; Stocks, Nigel; Moulding, Nicole

doi:10.5694/j.1326-5377.2006.tb00475.x

Cited by 37 publications

(28 citation statements)

References 16 publications

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“…Only two small studies investigated treatment with vitamin D [21, 22]; both were case series. Five studies were purely observational with no intervention [3, 23–26]. The total number of immigrant or ethnic minority patients in “pain” and “control” groups was 431.…”

Section: Resultsmentioning

confidence: 99%

“…One study [3] found lower levels of 25-OH vitamin D in eight Australian Aborigines affected by chronic pain than in eight Aboriginal controls. Another in the UK [25] found similar 25-OH vitamin D levels in 127 South Asians affected by chronic widespread pain as in South Asians diagnosed with specific rheumatic diseases.…”

Section: Resultsmentioning

confidence: 99%

“…Subjects with specific rheumatic diseases, however, are an inappropriate control for the question of this review because some of them may well have had chronic pain (which is why data from this group are not included as “controls” in Figure 1). The only study comparing 25-OH vitamin D levels in an ethnic minority group with chronic pain with controls from the same ethnic minority [3] did find lower levels of 25-OH vitamin D in the subjects with pain. However, this study was too small, with 16 subjects, to allow any meaningful interpretation.…”

Section: Discussionmentioning

confidence: 99%

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Vitamin D and Chronic Pain in Immigrant and Ethnic Minority Patients—Investigation of the Relationship and Comparison with Native Western Populations

Straube

Moore

Derry

et al. 2010

International Journal of Endocrinology

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Vitamin D deficiency has been implicated in chronic pain. Immigrant and ethnic minority populations have been shown to have lower vitamin D levels than native Western populations and often to be vitamin D deficient. This systematic review investigates the relationship between vitamin D and chronic pain in immigrant and ethnic minority populations. Included were studies reporting on 25-OH vitamin D levels in immigrant/ethnic minority populations affected by chronic pain, and/or reporting on the treatment of chronic pain with vitamin D preparations in such populations. We found that 25-OH vitamin D levels were low and often deficient in immigrant/ethnic minority populations. Vitamin D levels depended on the latitude of the study location and hence sunlight exposure. There was insufficient evidence to reach a verdict on the value of treating chronic pain in immigrant/ethnic minority patients with vitamin D preparations because the studies were few, small, and of low quality.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Vitamin D and Chronic Pain in Immigrant and Ethnic Minority Patients—Investigation of the Relationship and Comparison with Native Western Populations

Straube

Moore

Derry

et al. 2010

International Journal of Endocrinology

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“…Some types of musculoskeletal pain (e.g., fibromyalgia) likely occur independent of vitamin D status (de Rezende Pena et al, 2010; Heidari et al, 2010), but a substantial body of clinical data implicates vitamin D deficiency in nonspecific musculoskeletal pain (Gloth et al, 1991; Glerup and Eriksen, 1999; Plotnikoff and Quigley, 2003; Macfarlane et al, 2005; Benson et al, 2006; de Torrenté de la Jara et al, 2006; Heidari et al, 2010; McBeth et al, 2010) and suggests that supplementation attenuates pain in some individuals (Gloth et al, 1991; Glerup and Eriksen, 1999; de Torrenté de la Jara et al, 2006; Heaney, 2008). Nonetheless, the role of vitamin D in musculoskeletal pain remains controversial in light of limitations inherent to human clinical studies.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Deficiency Promotes Skeletal Muscle Hypersensitivity and Sensory Hyperinnervation

Tague¹,

Clarke²,

Winter³

et al. 2011

J. Neurosci.

112

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Musculoskeletal pain affects nearly half of all adults, most of whom are vitamin D deficient. Previous findings demonstrated that putative nociceptors (“pain-sensing” nerves) express vitamin D receptors (VDRs), suggesting responsiveness to 1,25-dihydroxyvitamin D. In the present study, rats receiving vitamin D-deficient diets for 2– 4 weeks showed mechanical deep muscle hypersensitivity, but not cutaneous hypersensitivity. Muscle hypersensitivity was accompanied by balance deficits and occurred before onset of overt muscle or bone pathology. Hypersensitivity was not due to hypocalcemia and was actually accelerated by increased dietary calcium. Morphometry of skeletal muscle innervation showed increased numbers of presumptive nociceptor axons (peripherin-positive axons containing calcitonin gene-related peptide), without changes in sympathetic or skeletal muscle motor innervation. Similarly, there was no change in epidermal innervation. In culture, sensory neurons displayed enriched VDR expression in growth cones, and sprouting was regulated by VDR-mediated rapid response signaling pathways, while sympathetic outgrowth was not affected by different concentrations of 1,25-dihydroxyvitamin D. These findings indicate that vitamin D deficiency can lead to selective alterations in target innervation, resulting in presumptive nociceptor hyperinnervation of skeletal muscle, which in turn is likely to contribute to muscular hypersensitivity and pain.

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“…For example, vitamin D deficiency is associated with chronic musculoskeletal pain and acroparaesthesia (numbness, burning, or tingling in the extremities) (Glerup and Eriksen, 1999; Gloth et al , 1991; Masood et al , 1989; Plotnikoff and Quigley, 2003). Over 85% of patients who report chronic musculoskeletal pain have levels of serum 25-hydroxyvitamin D 3 (25OHD 3 ) that are less than 20ng/ml (50nmol/L) (Benson et al , 2006; Macfarlane et al , 2005; Plotnikoff and Quigley, 2003), which is relieved by vitamin D supplementation (de Torrente de la Jara et al , 2006; Glerup and Eriksen, 1999; Gloth et al , 1991). However, the mechanism by which vitamin D deficiency leads to altered sensation is unknown.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D receptor and enzyme expression in dorsal root ganglia of adult female rats: Modulation by ovarian hormones

Tague

Smith

2011

Journal of Chemical Neuroanatomy

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Vitamin D insufficiency impacts sensory processes including pain and proprioception, but little is known regarding vitamin D signaling in adult sensory neurons. We analyzed female rat dorsal root ganglia (DRG) for vitamin receptor (VDR) and the vitamin D metabolizing enzymes CYP27B1 and CYP24. Western blots and immunofluorescence revealed the presence of these proteins in sensory neurons. Nuclear VDR immunoreactivity was present within nearly all neurons, while cytoplasmic VDR was found preferentially in unmyelinated calcitonin gene-related peptide (CGRP)-positive neurons, colocalizing with CYP27B1 and CYP24. These data suggest that 1,25(OH)2D3 may affect sensory neurons through nuclear or extranuclear signaling pathways. In addition, local vitamin D metabolite concentrations in unmyelinated sensory neurons may be controlled through expression of CYP27B1 and CYP24. Because vitamin D deficiency appears to exacerbate some peri-menopausal pain syndromes, we assessed the effect of ovariectomy on vitamin D-related proteins. Two weeks following ovariectomy, total VDR expression in DRG dropped significantly, owing to a slight decrease in the percentage of total neurons expressing nuclear VDR and a large drop in unmyelinated CGRP-positive neurons expressing cytoplasmic VDR. Total CYP27B1 expression dropped significantly, predominantly due to decreased expression within unmyelinated CGRP-positive neurons. CYP24 expression remained unchanged. Therefore, unmyelinated CGRP-positive neurons appear to have a distinct vitamin D phenotype with hormonally-regulated ligand and receptor levels. These findings imply that vitamin D signaling may play a specialized role in a neural cell population that is primarily nociceptive.

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Muscle pain as an indicator of vitamin D deficiency in an urban Australian Aboriginal population

Cited by 37 publications

References 16 publications

Vitamin D and Chronic Pain in Immigrant and Ethnic Minority Patients—Investigation of the Relationship and Comparison with Native Western Populations

Vitamin D and Chronic Pain in Immigrant and Ethnic Minority Patients—Investigation of the Relationship and Comparison with Native Western Populations

Vitamin D Deficiency Promotes Skeletal Muscle Hypersensitivity and Sensory Hyperinnervation

Vitamin D receptor and enzyme expression in dorsal root ganglia of adult female rats: Modulation by ovarian hormones

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