Muscle modifications in Parkinson's disease: myoelectric manifestations

Rossi, Bruno; Siciliano, Gabriele; Carboncini, Maria Chiara; Manca, Maria Laura; Massetani, R.; Viacava, Paolo; Muratorio, A

doi:10.1016/0924-980x(96)94672-x

Cited by 60 publications

(54 citation statements)

References 35 publications

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“…The selective atrophy of type II fibres with advancing age may partly explain poorer performance at high speeds 24 . Interestingly, muscles biopsies from persons with PD have shown increased type-I fibres and decreased type-II 25 . In addition, patients with PD exibit multiple agonist bursting during the acceleration phase of movement and increased antagonistic movement 26 .…”

Section: Discussionmentioning

confidence: 99%

Work and power reduced in L-dopa naïve patients in the early-stages of Parkinson’s disease

Lima

Cardoso

Teixeira-Salmela

et al. 2016

Arq. Neuro-Psiquiatr.

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Parkinson's disease (PD) is a neuro-degenerative disease in which the progressions of the symptoms are associated with progressive loss of strength and power, which leads to deterioration of physical abilities 1,2 . Studies that employed measures of peak torque have observed muscular deficits in individuals at various stages of PD, mainly in the intermediate and advanced phases 3,4 . Usually, these individuals demonstrated bilateral motor impairments, which are associated with deficits in balance and gait and may contribute to immobility and poorer functional performance 5 .Recently, studies have found that in the early stages, individuals with PD already demonstrate cognitive decline 6 , impaired planning 7 , altered dynamic postural control 8 , and functional losses when compared to those without the disease 9 . In addition to these impairments, it is possible that muscle deficits may also contribute to the functional losses. However, few studies have investigated muscular performance in individuals in the early stages of PD. Bridgewater and Sharpe 10 showed decreases in trunk extensor torque during the early-stages of PD, which could contribute to the flexed posture observed in the advanced stages. Koller and Kase 11 observed decreases in the maximal isotonic knee strength of individuals in the early stages of the disease; however, the hip and ankle muscular groups were not assessed. Furthermore, several studies have AbstrACtStudies which have investigated muscular performance during the initial stages of Parkinson´s disease (PD) without L-dopa treatments were not found. Objective: to assess whether muscular performance, work and power, of the trunk and lower limbs in L-dopa naïve patients in the early stages of PD was lower than those of healthy subjects and to compare muscular performance between the lower limbs. Method: Ten subjects with PD, Hoehn and Yahr (HY) I-II, L-dopa naïve and 10 subjects in the control group were assessed with the isokinetic dynamometer. Results: ANOVAs revealed that work and power measures of the trunk, hip, knee, and ankle muscular groups were lower in PD compared with the control group (p < 0.05). There were no significant differences in muscular performance between the lower limbs. Conclusion:The results suggested the use of specific exercises, as rehabilitation strategies, to improve the ability to produce work and power with this population.Keywords: Parkinson's disease; muscle strength; Muscle strength dynamometer; rehabilitation; physical therapy speciality. resumo Estudos que investigaram o desempenho muscular durante os estágios iniciais da doença de Parkinson (DP), sem tratamento com L-dopa não foram encontrados. Objetivo: Avaliar se o desempenho muscular, por meio de medidas de trabalho e potência, do tronco e dos membros inferiores em pacientes sem o uso de L-dopa nas fases iniciais da DP é menor do que o de indivíduos saudáveis e comparar o desempenho muscular entre os membros inferiores. Método: Dez indivíduos com DP, Hoehn and Yahr (HY) I-II, sem L-dopa e 10 indiv...

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Section: Discussionmentioning

confidence: 99%

Work and power reduced in L-dopa naïve patients in the early-stages of Parkinson’s disease

Lima

Cardoso

Teixeira-Salmela

et al. 2016

Arq. Neuro-Psiquiatr.

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“…Rossi et al [39] examined PD subjects for peripheral mechanisms of fatigue. Based on (tibialis anterior) muscle biopsies from a small group of PD subjects, they found signs of reduced peripheral fatigability, such that type I fibers had increased prevalence and tended to hypertrophy.…”

Section: Discussionmentioning

confidence: 99%

Perceptions of effort during handgrip and tongue elevation in Parkinson's disease

Solomon

Robin

2005

Parkinsonism & Related Disorders

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Background-Fatigue and the accompanying perception of effort are often heightened in Parkinson's disease.Objectives-To compare performance on three sense-of-effort tasks between patients with PD and matched neurologically normal control subjects.Methods-Sixteen PD subjects and 16 normal subjects performed three tasks to assess sense of effort: self-ratings of effort using direct-magnitude estimation, generating pressures at various levels of effort, and sustaining a submaximal level of effort. The latter two tasks were done with handgrip and tongue elevation.Results-Two of the three tasks successfully differentiated the groups. Subjects with PD provided significantly higher ratings of effort for general daily activities and for speech. During the constant-effort task, pressure curves decayed more rapidly for the PD subjects.Conclusions-Performance by PD subjects on the constant-effort task resembled that by normal adults who were pre-fatigued in previous experiments. Results support greater than normal senseof-effort related to fatigue in PD, and provide preliminary validation of a performance-based physiologic task to assess abnormal sense of effort in this population.

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“…Reports of firing irregularities of single motor units in PD have been attributed to an alteration of central input to the motor neuron pool (Dengler et al 1990;Glendinning and Enoka 1994). In addition, increased type I fibres and decreased type II fibres have been reported in individuals with PD, suggesting peripheral muscle changes (Edstrom 1970;Rossi et al 1996) resulting from the disease process or perhaps from impaired mobility and the resulting sedentary lifestyle.…”

Section: Altered Movement Strategymentioning

confidence: 99%

Postural control during a sit-to-stand task in individuals with mild Parkinson's disease

Inkster

Eng

2004

Experimental Brain Research

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Individuals with Parkinson's disease (PD) typically have difficulty rising from a chair. A major contributing factor may be altered anticipatory postural control; this hypothesis has been fueled by reports of altered function of the supplementary motor area in PD, an area linked to the preparation of movements. This study tested the hypothesis that individuals with PD would exhibit altered anticipatory postural control which would include a reduced preparatory hip flexion and decreased forward displacement of the COM prior to lift-off of the buttocks from the chair. Ten male subjects with PD and 10 male age-matched controls were instructed to rise from a chair without the use of their arms at their comfortable pace on two separated days during on and offmedication states. Body movements were recorded with an optoelectronic device, in addition to forces under the buttocks and each foot to calculate lower extremity joint angles, joint moments and net body centre of mass displacement (COM). The sit-to-stand (STS) duration was the same for the PD-on and controls, but greater for the PD-off group. The PD groups (on and off) used a hip flexion strategy (greater preparatory hip flexion displacement and forward COM displacement, reduced knee extensor moments) compared to the controls. Contrary to predictions, subjects with PD exaggerated, rather than reduced, the movement preparation of the STS using a hip flexion strategy. Possible underlying causes of this flexion strategy could include compensation for poor lower extremity muscle strength and a need for greater postural stability during the lift-off phase.

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Muscle modifications in Parkinson's disease: myoelectric manifestations

Cited by 60 publications

References 35 publications

Work and power reduced in L-dopa naïve patients in the early-stages of Parkinson’s disease

Work and power reduced in L-dopa naïve patients in the early-stages of Parkinson’s disease

Perceptions of effort during handgrip and tongue elevation in Parkinson's disease

Postural control during a sit-to-stand task in individuals with mild Parkinson's disease

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