Muscle metaboreflex control is diminished in normotensive obese women

Negräo, Carlos Eduardo; Trombetta, Ivani C.; Batalha, L. T.; Ribeiro, M. M.; Rondon, Maria Urbana Pinto Brandão; Tinucci, Taís; Forjaz, C. L. M.; Barretto, Antônio Carlos Pereira; Halpern, Alfredo; Villares, S M

doi:10.1152/ajpheart.2001.281.2.h469

Cited by 94 publications

(86 citation statements)

References 21 publications

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“…Although obesity appears to reduce resting FBF, 5,6 contraction-induced increases in FBF 5 during and after arm exercise appear not to be influenced by obesity 29 and aging. 30 Fahs et al 16 demonstrated a local increase in FBF and vasodilatory capacity 25 min after a bout of arm and chest resistance exercise.…”

Section: Discussionmentioning

confidence: 80%

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Effects of resistance exercise training on resting and post-exercise forearm blood flow and wave reflection in overweight and obese women

Kingsley

Figueroa

2011

J Hum Hypertens

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The vascular responses to acute resistance exercise and resistance exercise training (RET) in overweight women are unclear. Therefore, the purpose of this study was to examine the vasodilatory and wave reflection responses to acute resistance exercise before and after RET. In all, 24 overweight/obese (28.5 ± 0.6 kg m À2 ) women (44 ± 1 years of age) volunteered for this study. Forearm blood flow (FBF), vasodilatory capacity in response to reactive hyperemia (peak FBF) and wave reflection (radial tonometry) were measured, before and 15 min after five sets of leg press at 10-repetition maximum (RM). Measures of pulse wave reflection included the augmentation index (AIx) and the time of the reflected wave (Tr). Measurements were collected at baseline, after a 4-week control period (before RET) and after 12 weeks of whole-body RET using three sets of five exercises at 50-60% of 1-RM. There were no differences in vascular measurements at baseline or before RET for any variable. Resting FBF (66.7%) and peak FBF (51.6%) increased significantly (Po0.05) after RET compared with before RET. Postexercise FBF (48.9%) and peak FBF (41.1%) also increased significantly (Po0.05) after RET compared with before RET. Post-exercise AIx decreased significantly (Po0.05), whereas Tr increased significantly (Po0.05) compared with rest at all time points. However, AIx and Tr were unaltered by RET. The 12-week wholebody RET increased the resting and post-exercise FBF as well as vasodilatory capacity without changing wave reflection in premenopausal overweight women. RET may be an important non-pharmacological therapy for reducing cardiovascular risk in overweight and obese premenopausal women.

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Section: Discussionmentioning

confidence: 80%

“…4 Resting forearm blood flow (FBF) 5 and vasodilatory capacity 6 are decreased in overweight and obese adults. Obesity is also associated with increased augmentation index (AIx), 7 a measure of pressure wave reflection that is reduced by vasodilation of muscular arteries.…”

Section: Introductionmentioning

confidence: 99%

Effects of resistance exercise training on resting and post-exercise forearm blood flow and wave reflection in overweight and obese women

Kingsley

Figueroa

2011

J Hum Hypertens

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“…During the handgrip exercise, blood pressure was monitored noninvasively and intermittently with the use of an automatic oscillometric cuff (DX 2710; Dixtal, Manaus, Brazil) placed on the ankle with cuff width adjusted to ankle circumference (30,31). Heart rate was monitored continuously through lead II of the ECG.…”

Section: Peripheral Vascular Reactivity Evaluationmentioning

confidence: 99%

Peripheral vascular reactivity and serum BDNF responses to aerobic training are impaired by the BDNF Val66Met polymorphism

Lemos

Alves

Souza

et al. 2016

Physiological Genomics

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-Besides neuronal plasticity, the neurotrophin brain-derived neurotrophic factor (BDNF) is also important in vascular function. The BDNF has been associated with angiogenesis through its specific receptor tropomyosin-related kinase B (TrkB). Additionally, Val66Met polymorphism decreases activity-induced BDNF. Since BDNF and TrkB are expressed in vascular endothelial cells and aerobic exercise training can increase serum BDNF, this study aimed to test the hypotheses: 1) Serum BDNF levels modulate peripheral blood flow; 2) The Val66Met BDNF polymorphism impairs exercise training-induced vasodilation. We genotyped 304 healthy male volunteers (Val66Val, n ϭ 221; Val66Met, n ϭ 83) who underwent intense aerobic exercise training on a running track three times/wk for 4 mo. We evaluated pre-and post-exercise training serum BDNF and proBDNF concentration, heart rate (HR), mean blood pressure (MBP), forearm blood flow (FBF), and forearm vascular resistance (FVR). In the pre-exercise training, BDNF, proBDNF, BDNF/proBDNF ratio, FBF, and FVR were similar between genotypes. After exercise training, functional capacity (V O2 peak) increased and HR decreased similarly in both groups. Val66Val, but not Val66Met, increased BDNF (interaction, P ϭ 0.04) and BDNF/proBDNF ratio (interaction, P Ͻ 0.001). Interestingly, FBF (interaction, P ϭ 0.04) and the FVR (interaction, P ϭ 0.01) responses during handgrip exercise (HG) improved in Val66Val compared with Val66Met, even with similar responses of HR and MBP. There were association between BDNF/proBDNF ratio and FBF (r ϭ 0.64, P Ͻ 0.001) and FVR (r ϭ Ϫ0.58, P Ͻ 0.001) during HG exercise. These results show that peripheral vascular reactivity and serum BDNF responses to exercise training are impaired by the BDNF Val66Met polymorphism and such responsiveness is associated with serum BDNF concentrations in healthy subjects.BDNF Val66Met polymorphism; exercise training; vascular reactivity EXERCISE TRAINING HAS BEEN considered a key element in the improvement in brain-derived neurotrophic factor (BDNF) levels (39), which is the strongest factor linking exercise with cognitive benefits. However, the variability of individual responses may be linked to genetic differences.While BDNF promotes neuronal survival and enhanced synaptic plasticity by activating the tropomyosin kinase B (TrkB) receptor, the action of its precursor proBDNF results in apoptosis by interacting with the p75 neurotrophin receptor (p75NTR), and both are significantly involved in different physiological functions (15,53).Considering the fact that the BDNF gene and its TrkB receptor are expressed in several tissues, such as brain, heart, lungs, and endothelial cells (12, 28), besides neuronal plasticity, it is possible that the neurotrophin BDNF also is involved in the health of other tissues. Indeed, besides the hippocampus, the circulating BDNF is produced by a number of peripheral nonneuronal tissues, including vascular endothelial cells (28,53). Moreover, the neurotrophin BDNF has been associated with angiogenesis thro...

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“…Forearm blood flow was measured by venous occlusion plethysmography (Hokanson, Bellevue, USA), with the dominant arm positioned above heart level as described elsewhere. [14][15][16] Forearm blood flow (in ml/min/ 100 ml) was determined on the basis of a minimum of four separate readings. Forearm vascular resistance was calculated by dividing mean arterial pressure (expressed in mm Hg) by forearm blood flow (expressed in ml/min/100 ml tissue) and expressed in units.…”

Section: Haemodynamic Measurementsmentioning

confidence: 99%

Acute water ingestion increases arterial blood pressure in hypertensive and normotensive subjects

et al. 2007

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In patients with severe autonomic dysfunction, water ingestion elicits an acute pressor response. Hypertension may be associated with changes in cardiovascular autonomic modulation, but there is no information on the acute effects of water ingestion in patients with hypertension. In this study, we compared the effect of acute water ingestion on haemodynamic and autonomic responses of hypertensive and normotensive individuals. Eight patients with mild hypertension were compared to 10 normotensive individuals. After 30 min resting in the supine position all subjects ingested 500 ml of water. At baseline and after water ingestion, venous blood samples for plasma volume determination were collected, and electrocardiographic tracings, finger blood pressure, forearm blood flow and muscle sympathetic nerve activity (MSNA) were obtained. Water ingestion resulted in similar and minor reduction in plasma volume. Systolic and diastolic blood pressure increased in both hypertensive (mean7s.d.: 19/1476/ 3 mm Hg) and normotensive subjects (17/1476/3 mm Hg). There was an increase in forearm vascular resistance and in MSNA. Heart rate was reduced (hypertensive: 571 beats/min, normotensive: 576 beats/min) and the high-frequency component of heart rate and systolic blood pressure variability was increased. In hypertensive and normotensive individuals, acute water ingestion elicits a pressor response, an effect that is most likely determined by an increased vasoconstrictor sympathetic activity, and is counterbalanced by an increase in blood pressure and heart rate vagal modulation.

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Muscle metaboreflex control is diminished in normotensive obese women

Cited by 94 publications

References 21 publications

Effects of resistance exercise training on resting and post-exercise forearm blood flow and wave reflection in overweight and obese women

Effects of resistance exercise training on resting and post-exercise forearm blood flow and wave reflection in overweight and obese women

Peripheral vascular reactivity and serum BDNF responses to aerobic training are impaired by the BDNF Val66Met polymorphism

Acute water ingestion increases arterial blood pressure in hypertensive and normotensive subjects

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