Muscle histochemistry in chronic alcoholism

Ferraz, Maria Lucia Gomes; Gabbai, Alberto Alain; Oliveira, Acary Souza Bulle; Ferrari, A. P. J.; Miszputen, S. J.; A, Ferreira Neto; A, Castelo Filho; Schmidt, Beny

doi:10.1590/s0004-282x1989000200003

Cited by 4 publications

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References 20 publications

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“…Based on clinical and histological tests of the muscles, studies have demonstrated that chronic alcoholics show different degrees of muscle weakness, which can evolve to an acute condition of alcoholic myopathy. Muscle atrophy, type-grouping formation, proliferation, and in parallel, mitochondrial accumulation are serious alterations that deserve attention ( 2 , 3 ) .…”

Section: Introductionmentioning

confidence: 99%

Efeito da estimulação elétrica neuromuscular nas reservas de glicogênio muscular em razão da ingestão de etanol: estudo em ratos

Limoni

Arruda

2013

Einstein (São Paulo)

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Objective:To evaluate the effects of alcoholic ingestion and neurostimulation on the muscle glycogen reserve, body weight, blood sugar, and weight of the soleus muscle.Methods:Twenty male rats were distributed into four experimental groups (n=5), namely, Control, Ethanol, Electrostimulated, and Ethanol+Electrostimulated. The study lasted for 22 days. The groups submitted to the use of ethanol received the substance diluted in water, which was consumed during the entire experimental period. The groups that received electrostimulation, undersedationfor the procedure, had their left hind leg shaved, and the current was applied daily for 7 days, in 20-minute sessions. Next, after induced alcoholism and electrical stimulation in the corresponding groups, the animals were euthanized so that their muscles could be sent for glycogen analysis.Results:The Ethanol group displayed a lower body weight when compared to the Control and Electrostimulated groups; the Ethanol+Electrostimulated groups had a lower body weight compared to the Control and Electrostimulated groups, but were in a better situation when compared to the Ethanol group. As to glycogen capture, it was noted that the Ethanol group demonstrated resistance to blood glucose capture, whereas the Ethanol Electrostimulated group showed better capture than the other groups. As to muscle weight, it was observed that the Ethanol group had a lower weight than did the Controls, and that the Electrostimulated group weight greater when compared to the Control and Ethanol groups, respectively. On the other hand, the Ethanol+Electrostimulated groups showed no significant difference relative to the Controls, but had better results when compared to the Ethanol group.Conclusion:Chronic exposure to alcohol showed a direct relationship with reduced muscle and body weight, and in glycogen capture and muscle reserves, besides favoring innumerous organic disorders, thus interfering in rehabilitation processes.

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Section: Introductionmentioning

confidence: 99%