Andrea del Campo, Ignacio Contreras-Hernández, Mauricio Castro-Sepúlveda, Cristian A. Campos, Reinaldo Figueroa, María Florencia Tevy, Verónica Eisner, Mariana Casas, Enrique Jaimovich
Abstract:Sarcopenia is the degenerative loss of muscle mass and strength with aging. Although a role of mitochondrial metabolism in muscle function and in the development of many diseases has been described, the role of mitochondrial topology and dynamics in the process of muscle aging is not fully understood. This work shows a time line of changes in both mitochondrial distribution and skeletal muscle function during mice lifespan. We isolated muscle fibers from flexor digitorum brevis of mice of different ages. A fus…
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