2018
DOI: 10.18632/aging.101358
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Abstract: Sarcopenia is the degenerative loss of muscle mass and strength with aging. Although a role of mitochondrial metabolism in muscle function and in the development of many diseases has been described, the role of mitochondrial topology and dynamics in the process of muscle aging is not fully understood. This work shows a time line of changes in both mitochondrial distribution and skeletal muscle function during mice lifespan. We isolated muscle fibers from flexor digitorum brevis of mice of different ages. A fus… Show more

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Cited by 71 publications
(76 citation statements)
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References 58 publications
(69 reference statements)
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“…These included (i) young wild‐type (YWT) mice that were 20–30 weeks of age, (ii) older wild‐type mice that were 80–120 weeks of age (WT‐80), (iii) SIRT1 overexpressor older mice that were 80–120 weeks of age (OE‐80), (iv) SIRT1 older adult skeletal‐muscle knockout mice that were 80–120 weeks of age (MKO‐80), and (v) SIRT1 satellite cell knockout mice that were 80–120 weeks of age (SKO‐80). As ~50% of the animals died before they were 120 weeks of age, we chose to include older animals that were 80 weeks of age in our oldest group because this is at a point where muscle signalling changes and muscle atrophy and function begins to deteriorate . While these animals could not yet be considered to be old, this group had mice that ranged in age from 80–120 weeks, and the oldest animals in this group would be considered old.…”
Section: Methodsmentioning
confidence: 99%
“…These included (i) young wild‐type (YWT) mice that were 20–30 weeks of age, (ii) older wild‐type mice that were 80–120 weeks of age (WT‐80), (iii) SIRT1 overexpressor older mice that were 80–120 weeks of age (OE‐80), (iv) SIRT1 older adult skeletal‐muscle knockout mice that were 80–120 weeks of age (MKO‐80), and (v) SIRT1 satellite cell knockout mice that were 80–120 weeks of age (SKO‐80). As ~50% of the animals died before they were 120 weeks of age, we chose to include older animals that were 80 weeks of age in our oldest group because this is at a point where muscle signalling changes and muscle atrophy and function begins to deteriorate . While these animals could not yet be considered to be old, this group had mice that ranged in age from 80–120 weeks, and the oldest animals in this group would be considered old.…”
Section: Methodsmentioning
confidence: 99%
“…Functional and morphological studies suggest that early decline in muscle function starts at 12-months in C57BL/6J WT mice 62 . Interestingly, significant reduction in size, orientation, basal calcium content and fission/fusion proteins in mitochondria in the hindlimb FDB muscle were evident in C57BL/6J WT male mice of 10-14 months of age, suggesting incipient muscle decline 63 . Similarly, sarcopenia and obvious changes in NMJ architecture are evident in 18-month old healthy WT mice 2,46,64,65 .…”
Section: Discussionmentioning
confidence: 98%
“…Transcriptional profiling across species has identified downregulation of mitochondrial genes in skeletal muscle as a common aging signature [78,79], whereas loss of skeletal muscle mitochondrial function is associated with age-related sarcopenia in C. elegans [80,81] and mice. Candidate gene studies on aging have implicated genes with important roles in skeletal muscle metabolism, including IGF1R, AKT1 and FOXO3A [82,83], genes that are also linked to mTORC1 signaling.…”
Section: Discussionmentioning
confidence: 99%