2006
DOI: 10.1111/j.1743-6109.2006.00113.x
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Stem cells derived from adult tissues may serve as cell therapy to enhance the healing process in skin wounds. This study was designed to evaluate the use of autologous muscle-derived stem cells in an experimental skin wound model in terms of their efficiency at promoting tissue repair/regeneration. Muscle-derived cells obtained from the dorsal muscle of New Zealand rabbits were cultured in vitro for 2 weeks. The cell population was identified using the satellite markers CD34, m-cadherin and Myf5, and the prol… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
13
0

Year Published

2007
2007
2017
2017

Publication Types

Select...
6

Relationship

1
5

Authors

Journals

citations
Cited by 10 publications
(13 citation statements)
references
References 32 publications
0
13
0
Order By: Relevance
“…This experimental model has been validated in previous studies conducted by our group, allowing fast and easy macroscopic evaluation of the ischemic skin wounds. We reported that the use of muscle‐derived adult stem cells expedited and improved the healing of skin wounds . In addition, a promotor of angiogenesis, PAMP (proadrenomodullin N‐terminal 20 peptide), has been shown to improve wound healing in both normoxic and ischemic conditions .…”
Section: Discussionmentioning
confidence: 85%
See 3 more Smart Citations
“…This experimental model has been validated in previous studies conducted by our group, allowing fast and easy macroscopic evaluation of the ischemic skin wounds. We reported that the use of muscle‐derived adult stem cells expedited and improved the healing of skin wounds . In addition, a promotor of angiogenesis, PAMP (proadrenomodullin N‐terminal 20 peptide), has been shown to improve wound healing in both normoxic and ischemic conditions .…”
Section: Discussionmentioning
confidence: 85%
“…The rabbit model of ischemic ear ulcer, being well tolerated by animals, allows us to examine the importance of oxygen supply in wound healing, by disrupting blood supply and by creating an excisional wound living the deeper microcirculation intact. 8 This experimental model has been validated in previous studies conducted by our group, 9,16 allowing fast and easy macroscopic evaluation of the ischemic skin wounds. We reported that the use of muscle-derived adult stem cells expedited and improved the healing of skin wounds.…”
Section: Discussionmentioning
confidence: 89%
See 2 more Smart Citations
“…Samples explanted after 5 days were observed directly with a confocal microscope (TCS SP5, Leica, Barcelona, Spain) whereas samples after 14 days were embedded in paraffin, sectioned, stained with hematoxylin-eosin and histologically observed by optical microscopy. The induction of ischemia and wounding were performed as described previously [13,17]. Briefly, the central vein and artery of the ear were ligated at two points at the base of the ear using non-absorbable silk sutures (ASSUSILK 3/0, Assut Europe, Rome, Italy), and the portion of the vessels between the sutures were excised to ensure complete blood flow interruption.…”
Section: In Vivo Evaluation Of the Pro-angiogenic Properties Of The Hmentioning
confidence: 99%