2011
DOI: 10.1371/journal.pone.0027729
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: BackgroundPancreatic cancer is one of the most aggressive cancers, with tumor-induced myeloid-derived suppressor cells (MDSC) contributing to its pathogenesis and ineffective therapies. In response to cytokine/chemokine receptor activation, src homology 2 domain-containing inositol 5′-phosphatase-1 (SHIP-1) influences phosphatidylinositol-3-kinase (PI3K) signaling events, which regulate immunohomeostasis. We hypothesize that factors from murine pancreatic cancer cells cause the down-regulation of SHIP-1 expres… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

3
51
0

Year Published

2012
2012
2023
2023

Publication Types

Select...
10

Relationship

3
7

Authors

Journals

citations
Cited by 43 publications
(54 citation statements)
references
References 46 publications
3
51
0
Order By: Relevance
“…In contrast, the level of pSTAT3 in cytokine-treated cells was strongly elevated compared with nontreated cells, whereas the total amount of STAT3 in both cells was nearly the same. These data are in agreement with the previous observation that the reduction of SHIP-1 and PTEN levels results in an increase in STAT3 activity, leading to MDSC expansion (33,34). Next, we sorted MDSC from tumor-bearing mice and compared their PTEN, SHIP-1, pSTAT3, and STAT3 levels with those in peripheral leukocytes from control mice.…”
Section: Mir-155 and Mir-21 Synergistically Enhance Mdsc Expansion VIsupporting
confidence: 91%
“…In contrast, the level of pSTAT3 in cytokine-treated cells was strongly elevated compared with nontreated cells, whereas the total amount of STAT3 in both cells was nearly the same. These data are in agreement with the previous observation that the reduction of SHIP-1 and PTEN levels results in an increase in STAT3 activity, leading to MDSC expansion (33,34). Next, we sorted MDSC from tumor-bearing mice and compared their PTEN, SHIP-1, pSTAT3, and STAT3 levels with those in peripheral leukocytes from control mice.…”
Section: Mir-155 and Mir-21 Synergistically Enhance Mdsc Expansion VIsupporting
confidence: 91%
“…Regulatory T cells (Tregs) or myeloid derived suppressors cells (MDSC) are also known to blunt T cell responses (12,13). Tregs suppress antigen-specific T cell response and removal of Tregs in murine models led to enhanced anti-tumor T cell responses and tumor rejection (14).…”
Section: Introductionmentioning
confidence: 99%
“…79 In addition, SHIP-1-regulated MDSC expansion and function may contribute to pancreatic tumor progression. 80 …”
Section: Src Homology 2 Domain-containing Inositol 59-phosphatase-1mentioning
confidence: 99%