Murine models of myocardial and limb ischemia: Diagnostic end-points and relevance to clinical problems

Madeddu, Paolo; Emanueli, Costanza; Spillmann, Frank; Meloni, Marco; Bouby, Nadine; Richer, Christine; Alhenc-Gélas, François; Weel, Vincent van; Eefting, D.; Quax, Paul H.A.; Hu, Yanjun; Xu, Qingbo; Hemdahl, Anne-Louise; Golde, Jolanda van; Huijberts, M. S. P.; Lussanet, Q. de; Boudier, Harry Struijker; Couffinhal, Thierry; Duplàa, C.; Chimenti, Stefano; Staszewsky, Lidia; Latini, Roberto; Baumans, V.; Lévy, Bernard

doi:10.1016/j.vph.2006.08.008

Cited by 49 publications

(35 citation statements)

References 92 publications

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“…Only in experimental animal angiography studies, but not in their clinical counterparts, is an angiographic classification for assessing peripheral collaterals currently used (0=no filling of collaterals, 1=fill-ing of collaterals only, 2=partial filling of distal femoral artery, and 3=complete filling of distal femoral artery). 17 Alternatively, a transverse line marking the inferior border of the obliteration can be drawn, and all vessels that cross the line at the inferior border can be counted as collaterals. 7 Although this method has been used successfully in a clinical study identifying risk factors for poor collateral development in PAD, 7 its use may lead to a rather arbitrary classification of collaterals.…”

Section: Discussionmentioning

confidence: 99%

Direct Quantitative Assessment of the Peripheral Artery Collateral Circulation in Patients Undergoing Angiography

et al. 2013

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Background-Despite the fact that numerous studies have pursued the strategy of improving collateral function in patients with peripheral artery disease, there is currently no method available to quantify collateral arterial function of the lower limb. Methods and Results-Pressure-derived collateral flow index (CFIp, calculated as (occlusive pressure−central venous pressure)/(aortic pressure−central venous pressure); pressure values in mm Hg) of the left superficial femoral artery was obtained in patients undergoing elective coronary angiography using a combined pressure/Doppler wire (n=30). Distal occlusive pressure and toe oxygen saturation (Sao 2 ) were measured for 5 minutes under resting conditions, followed by an exercise protocol (repetitive plantar-flexion movements in supine position; n=28). In all patients, balloon occlusion of the superficial femoral artery over 5 minutes was painless under resting conditions. CFIp increased during the first 3 minutes from 0.451±0.168 to 0.551±0.172 (P=0.0003), whereas Sao 2 decreased from 98±2% to 93±7% (P=0.004). Maximal changes of Sao 2 were inversely related to maximal CFIp (r 2 =0.33, P=0.003). During exercise, CFIp declined within 1 minute from 0.560±0.178 to 0.393±0.168 (P<0.0001) and reached its minimum after 2 minutes of exercise (0.347±0.176), whereas Sao 2 declined to a minimum of 86±6% (P=0.002). Twenty-five patients (89%) experienced pain or cramps/tired muscles, whereas 3 (11%) remained symptom-free for an occlusion time of 10 minutes. CFIp values were positively related to the pain-free time span (r 2 =0.50, P=0.002). Conclusions-Quantitatively assessed collateral arterial function at rest determined in the nonstenotic superficial femoral artery is sufficient to prevent ischemic symptoms during a total occlusion of 5 minutes. During exercise, there is a decline in CFIp that indicates a supply-demand mismatch via collaterals or, alternatively, a steal phenomenon. Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01742455.(Circulation. 2013;128:737-744.)

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Section: Discussionmentioning

confidence: 99%

Direct Quantitative Assessment of the Peripheral Artery Collateral Circulation in Patients Undergoing Angiography

et al. 2013

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“…In addition, we noted increased number of necrotic toes of Nrf2 + / + mice ( p = 0.075 vs. Nrf2 -/ -) (Fig. 7C), the evaluation of which provides an additional method of estimating the rate of recovery after ischemia (38). However, we did not observe any significant differences in the number of blood vessels (capillaries and small arteries) in the ischemic muscles of Nrf2 + / + and Nrf2 -/ -mice at day 21 after FAL (not shown).…”

Section: Lack Of Nrf2 Modulates Revascularization After Falmentioning

confidence: 91%

Nrf2 Regulates Angiogenesis: Effect on Endothelial Cells, Bone Marrow-Derived Proangiogenic Cells and Hind Limb Ischemia

Florczyk

Jaźwa

Maleszewska

et al. 2014

Antioxidants & Redox Signaling

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Aims: Nuclear factor E2-related factor 2 (Nrf2), a key cytoprotective transcription factor, regulates also proangiogenic mediators, interleukin-8 and heme oxygenase-1 (HO-1). However, hitherto its role in blood vessel formation was modestly examined. Particularly, although Nrf2 was shown to affect hematopoietic stem cells, it was not tested in bone marrow-derived proangiogenic cells (PACs). Here we investigated angiogenic properties of Nrf2 in PACs, endothelial cells, and inflammation-related revascularization. Results: Treatment of endothelial cells with angiogenic cytokines increased nuclear localization of Nrf2 and induced expression of HO-1. Nrf2 activation stimulated a tube network formation, while its inhibition decreased angiogenic response of human endothelial cells, the latter effect reversed by overexpression of HO-1. Moreover, lack of Nrf2 attenuated survival, proliferation, migration, and angiogenic potential of murine PACs and affected angiogenic transcriptome in vitro. Additionally, angiogenic capacity of PAC Nrf2

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“…This method measures reduced ischemia-induced angiogenesis in the smaller vessels of the gastrocnemius that are sufficiently deep into the limb so as not to be detected by LDI. 38 Thus, both large and small arterial vessel angiogenesis is impaired in PRCP-deficient mice.…”

Section: Discussionmentioning

confidence: 99%

Prolylcarboxypeptidase promotes angiogenesis and vascular repair

Adams¹,

Stavrou²,

Fang³

et al. 2013

Blood

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Murine models of myocardial and limb ischemia: Diagnostic end-points and relevance to clinical problems

Cited by 49 publications

References 92 publications

Direct Quantitative Assessment of the Peripheral Artery Collateral Circulation in Patients Undergoing Angiography

Direct Quantitative Assessment of the Peripheral Artery Collateral Circulation in Patients Undergoing Angiography

Nrf2 Regulates Angiogenesis: Effect on Endothelial Cells, Bone Marrow-Derived Proangiogenic Cells and Hind Limb Ischemia

Prolylcarboxypeptidase promotes angiogenesis and vascular repair

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