Wastewater treatment plants face enormous economic, environmental, technical, and regulatory challenges, including the high energy costs of their operation, waste generation, and the destination of treated water. In this regard, a proposal was made for the operation of municipal WWTPs in Mexico, based on the symbiosis of the circular economy and eco-innovation as strategies for sustainable change in their operation. As a result, it was possible to obtain an updated diagnosis of the situation of the WWTPs, a proposal for their operation was made, and a circular and innovative business model was established for these plants in order to channel decision-making and visualize the path for the transition of these facilities to sustainable operation.