Multivalent cyclic template-directed synthesis of polycyclodextrin-based nanocarriers for enhanced chemotherapy

A cyclic brush zwitterionic polymer based pH-responsive nanocarrier-mediated dual drug delivery system with lubrication maintenance for osteoarthritis treatment

“…l -P(HEMA) 50 -Br and c -P(HEMA) 50 were prepared by ATRP and intrachain click cyclization according to our previous study. 44 The degree of polymerization (DP) of the P(HEMA) was calculated to be ∼50 by 1 H NMR spectra (Fig. S2, ESI†).…”

“…CB@Cur@LXP has a greater drug loading capacity than BB@Cur@LXP, which may be due to the greater stability of CB@Cur@LXP, which can better encapsulate drug molecules. 44 Cumulative release studies of Cur and LXP drugs were evaluated under physiological (pH 7.4) and acidic (pH 5.5) conditions, respectively (Fig. 3b–e), simulating the mixed pH of the OA microenvironment.…”

Designing a green poly(β-amino ester) for the delivery of nicotinamide drugs with biological activities and conducting a DFT investigation

“…2,3 Recent advancements in vehicular substances have provided an opportunity for chemotherapeutic agents to control their dispersion and selectivity in the body, thereby reducing their harmful complications. [4][5][6] Given their unique properties, numerous polymers have been identied as potential pharmaceutical delivery systems for chemotherapy drugs, which oen have signicant side effects. [7][8][9][10][11][12] Biodegradable polymers have proven to be essential in various medical and related applications.…”