2014
DOI: 10.1021/ac502276w
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Sensitive detection of cancer cells plays a critically important role in the early detection of cancer and cancer metastasis. However, because circulating tumor cells are extremely rare in peripheral blood, the detection of cancer cells with high analytical sensitivity and specificity remains challenging. Here, we have demonstrated a simple, sensitive and specific detection of cancer cells with the detection sensitivity of four cancer cells, which is lower than the cutoff value with respect to correlation with… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

0
110
0

Year Published

2016
2016
2022
2022

Publication Types

Select...
9
1

Relationship

2
8

Authors

Journals

citations
Cited by 152 publications
(110 citation statements)
references
References 47 publications
0
110
0
Order By: Relevance
“…We also translated the DNA-based biosensing interface into an immunological one by site-specifically anchoring antibodies on individual TDNs, which led to a versatile protein-sensing platform 21 . Overall, our protocol has been standardized in our laboratory and successfully used to detect various types of targets, including DNA, RNA, proteins, small molecules and whole cells [19][20][21][22][23][24][25][26][27] . A comprehensive overview of the protocol is provided in Figure 1.…”
mentioning
confidence: 99%
“…We also translated the DNA-based biosensing interface into an immunological one by site-specifically anchoring antibodies on individual TDNs, which led to a versatile protein-sensing platform 21 . Overall, our protocol has been standardized in our laboratory and successfully used to detect various types of targets, including DNA, RNA, proteins, small molecules and whole cells [19][20][21][22][23][24][25][26][27] . A comprehensive overview of the protocol is provided in Figure 1.…”
mentioning
confidence: 99%
“…Aptamers for various types of cancer cells were also prepared and used to detect circulating tumor cells in blood, and provided useful information on metastatic relapse for efficient therapy. 352,353 (b) Aptamer-Based DNA Assemblies for Sensing; Simple but very convenient sensing systems can be constructed by caging a variety of agents into aptamer-based hydrogels. These hydrogels are formed from two (or more) different DNA strands, bound to base-polymers, and aptamer-carrying linker(s), as schematically presented in Figure 17.…”
Section: Sensing In Vivo and In Vitromentioning
confidence: 99%
“…This hybridization event is then transduced into electrochemical signals through the specific binding of an avidin-HRP (horseradish peroxidase) conjugate to the biotin, leading to enzyme turnover-based signal transduction. A similar strategy, combined with multibranched hybridization chain reaction (mHCR) for improved sensitivity, was used for cancer cell detection [40]. Moreover, by conjugating the DNA tetrahedral probe to an antibody (e.g., tumor necrosis factor alpha), the strategy has been redesigned for immunological sensing as well [41].…”
Section: Electrochemical Readoutmentioning
confidence: 99%