Multispectral optoacoustic tomography of systemic sclerosis

Abstract

The study aimed to evaluate the clinical feasibility of hybrid ultrasound/multispectral optoacoustic tomography (MSOT) for assessing microvascular dysfunction in systemic sclerosis (SSc). A handheld US/MSOT imaging system was applied for imaging patients diagnosed with SSc (n = 7) and healthy volunteers (n = 8). Semiquantitative MSOT values for deoxygenated (HbR), oxygenated (HbO ) and total haemoglobin (HbT) were analysed for subcutaneous finger tissue of both hands (8 fingers per subject, 120 fingers in total) and used to assess disease activity (progressive vs stable). Grouped data were compared by one-way nested analysis of variance, Tukey post-hoc test as well as student's t test were used for statistical analysis.Subcutaneous finger tissue of patients with SSc provided significantly lower MSOT values for HbO (26.16 ± 0.71 vs 38.2 ± 1.54, P = .023) and HbT (55.92 ± 1.62 vs 72.46 ± 1.90, P = .018) compared to healthy volunteers. Patients with progressive SSc had significantly lower MSOT values compared to patients with stable disease and healthy volunteers.This pilot study shows the feasibility of MSOT imaging to resolve microvascular dysfunction in SSc as a marker of disease activity. By providing biological tissue properties not revealed by other imaging modalities, MSOT might help to grade SSc non-invasively and monitor early therapy response.

Multispectral Optoacoustic Tomography of Benign and Malignant Thyroid Disorders: A Pilot Study

“…We used a hybrid clinical MSOT/ultrasound imaging system (MSOT Acuity Echo; iThera Medical) previously described in detail elsewhere (15,21). Laser excitation pulses had a duration of 9 ns with a repetition rate of 25 Hz.…”

Shedding light on pediatric diseases: multispectral optoacoustic tomography at the doorway to clinical applications

“…In a consecutive study, the subcutaneous finger tissue of patients with systemic sclerosis (SSc) provided significantly lower MSOT values for oxygenated hemoglobin as well as total hemoglobin in comparison to healthy controls, reflecting microvascular dysfuntion in SSc as a possible marker of disease activity [37].…”

Optoakustische Bildgebung – Licht rein, Schall raus?

“…Ein kommerziell erwerbbares und zu Forschungszwecken CE-zertifiziertes Verfahren für makroskopische optoakustische Bildgebung ist die multispektrale optoakustische Tomografie (MSOT). Dieses System arbeitet mit Wellenlängen im Bereich 680 -980 Nanometer, ermöglicht Bildgebung in Echtzeit und kann je nach Ausführung auch konventionelle Ultraschallbilder parallel zu den optoakustischen Bildern aufnehmen [6].…”