1993
DOI: 10.1148/radiology.188.1.8511313
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Abstract: The authors developed a hydrogen-1 proton magnetic resonance (MR) imaging method in which metabolic information is acquired by obtaining multiple sections through the brain. A spin-echo sequence is used for section selection, an octangular outer volume saturation pulse for lipid suppression, and a chemical-shift-selective saturation pulse for water suppression. High-quality maps of choline, creatine, and N-acetylaspartate were obtained in six studies performed in four volunteers. Water and lipid signal from th… Show more

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Cited by 334 publications
(279 citation statements)
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“…Following sagittal scout images, a 4-section T1-weighted axial/oblique localizer imaging series, angulated parallel to the Sylvian fissure ( Figure 1A), was acquired, with a slice thickness of 15 mm and an inter-slice gap of 3.5 mm, matching the subsequent multislice 1 H MRSI scan. Next, the 1 H MRSI scan was performed using the method of Duyn et al (38), with TE/TR 280/2300 ms, FOV 240 mm, 32×32 circularly sampled k-space phase-encoding steps with 1 excitation per phase-encoding step, and 256 time-domain points. The strong pericranial lipid resonances from the skull, scalp and calvarial marrow were suppressed using octagonally tailored outer-volume suppression pulses, and water was suppressed with a single chemical shift-selective (CHESS) pulse followed by spoiler gradients.…”
Section: H Mrsi Data Acquisition Protocolmentioning
confidence: 99%
“…Following sagittal scout images, a 4-section T1-weighted axial/oblique localizer imaging series, angulated parallel to the Sylvian fissure ( Figure 1A), was acquired, with a slice thickness of 15 mm and an inter-slice gap of 3.5 mm, matching the subsequent multislice 1 H MRSI scan. Next, the 1 H MRSI scan was performed using the method of Duyn et al (38), with TE/TR 280/2300 ms, FOV 240 mm, 32×32 circularly sampled k-space phase-encoding steps with 1 excitation per phase-encoding step, and 256 time-domain points. The strong pericranial lipid resonances from the skull, scalp and calvarial marrow were suppressed using octagonally tailored outer-volume suppression pulses, and water was suppressed with a single chemical shift-selective (CHESS) pulse followed by spoiler gradients.…”
Section: H Mrsi Data Acquisition Protocolmentioning
confidence: 99%
“…Multiple slice 1 H-MRSI was performed on a conventional GE-SIGNA 1.5 Tesla MR imaging system (GE Medical Systems, Milwaukee, WI) equipped with self-shielded gradients using the method of Duyn et al (1993). The standard quadrature head coil was used in all exams.…”
Section: H-mrsi Proceduresmentioning
confidence: 99%
“…Each volume element had nominal dimensions of 7.5 mm ϫ 7.5 mm ϫ 15 mm (0.84 mL voxel). Actual volume, based on full width at half maximum (FWHM) after filtering of k-space, was 1.4 mL (Duyn et al 1993). …”
Section: H-mrsi Proceduresmentioning
confidence: 99%
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“…The symmetry is necessary because an asymmetric encode leads to unwanted phase cycling in the reconstructed image. Water suppression was obtained by using three consecutive chemical shift selective (CHESS) pulses (27) and fat suppression by using eight OVS slices (28), applied prior to the /2-pulse. The OVS slices were set apart from the brain in order to not reduce the signals of metabolites in the brain.…”
Section: Methodsmentioning
confidence: 99%