Multiplexed detection of biomarkers using a microfluidic chip integrated with mass-producible micropillar array electrodes

Chen, Chaozhan; Ran, Bin; Liu, Bo; Liu, Xiaoxuan; Zhang, Ziteng; Li, Yudong; Li, Hongchun; Lan, Minbo; Zhu, Yonggang

doi:10.1016/j.aca.2023.341450

Cited by 4 publications

(3 citation statements)

References 56 publications

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“…168 Pt–Pd bimetallic nanoclusters are used by Chen, Chaozhan, et al in a novel microfluidic device with mass-producible micropillar array electrodes for enhanced biomarker detection sensitivity, as demonstrated by notable improvements in H 2 O 2 detection and high-sensitivity biosensing of glucose, uric acid, and sarcosine in human serum. 169 A novel technique for early clinical sepsis detection was developed by Yin, Binfeng, et al , using commercially available 3M tapes inside a proprietary microfluidic device for automated and sensitive analysis of sepsis-related biomarkers in serum. As a promising platform for accurate clinical and field diagnostics, the tape-based microfluidic chip exhibits high sensitivity and selectivity in detecting C-reactive protein (CRP) with a limit of detection (LOD) of 0.23 g mL −1 , procalcitonin (PCT) at 0.14 ng mL −1 , and interleukin-6 (IL-6) at 12.53 pg mL −1 .…”

Section: Diseases Acute Nutritional Deficiencies Biomarkersmentioning

confidence: 99%

Integrated microfluidic devices for point-of-care detection of bio-analytes and disease

Behera,

Kumar,

Kumari

et al. 2023

Sens. Diagn.

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Section: Diseases Acute Nutritional Deficiencies Biomarkersmentioning

confidence: 99%

Integrated microfluidic devices for point-of-care detection of bio-analytes and disease

Behera,

Kumar,

Kumari

et al. 2023

Sens. Diagn.

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show abstract

“…Within a specific projection area, micropillar array electrodes offer a significantly larger surface area compared to planar electrodes due to their three-dimensional structure [ 8 , 9 ]. This expanded surface area allows micropillar array electrodes to interact with a larger volume of analytes, leading to enhanced current responses and sensitivities [ 10 , 11 ]. Applications of micropillar array electrodes span various fields, showcasing their performance advantages over planar electrodes.…”

Section: Introductionmentioning

confidence: 99%

“…The micropillar array electrodes demonstrated a 1.5 times larger sensitivity compared with the planar electrode when hydrogen peroxide was detected. Furthermore, they developed a microfluidic device integrated with polymethyl methacrylate (PMMA)-based micropillar array electrodes to detect multiple biomarkers [ 10 ]. The GOx-modified electrode exhibits a linear response to glucose from 0.1 mM to 12 mM, and the limit of detection (LOD) is 58.5 μM.…”

Section: Introductionmentioning

confidence: 99%

CTAB-Modulated Electroplating of Copper Micropillar Arrays for Non-Enzymatic Glucose Sensing with Improved Sensitivity

Yao,

He,

Wang

2024

Sensors

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Micropillar array electrodes represent a promising avenue for enhancing detection sensitivity and response current. However, existing methods for depositing electrode materials on micropillar arrays often result in uneven distribution, with the thin sidewall layer being less conductive and prone to corrosion. In addressing this issue, this study introduces electroplating to enhance the copper layer on the sidewall of micropillar array electrodes. These electrodes, fabricated through standard microelectronics processes and electroplating, are proposed for non-enzymatic glucose detection, with the copper layer deposited via electroplating significantly enhancing sensitivity. Initially, the impact of cetyltrimethylammonium bromide (CTAB) concentration as an inhibitor on the surface morphology and sensitivity of the plated layer was investigated. It was discovered that CTAB could decrease surface roughness, hinder the development of large and coarse grains, generate small particles, and boost sensitivity. Compared to the uncoated electrode and plating without CTAB, sensitivity was elevated by a factor of 1.66 and 1.62, respectively. Subsequently, the alterations in plating morphology and detection performance within a range of 0.3 ASD to 3 ASD were examined. Sensitivity demonstrated a tendency to increase initially and then decrease. The electrode plated at 0.75 ASD achieved a maximum sensitivity of 3314 μA·mM−1·cm−2 and a detection limit of 15.9 μM. Furthermore, a potential mechanism explaining the impact of different morphology on detection performance due to CTAB and current density was discussed. It was believed that the presented effective strategy to enhance the sensitivity of micropillar array electrodes for glucose detection would promote the related biomedical detection applications.

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Lab on a chip for detecting Clara cell protein 16 (CC16) for potential screening of the workers exposed to respirable silica aerosol

Ahn,

Lee,

Shin

et al. 2023

Microfluid Nanofluid

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Multiplexed detection of biomarkers using a microfluidic chip integrated with mass-producible micropillar array electrodes

Cited by 4 publications

References 56 publications

Integrated microfluidic devices for point-of-care detection of bio-analytes and disease

Integrated microfluidic devices for point-of-care detection of bio-analytes and disease

CTAB-Modulated Electroplating of Copper Micropillar Arrays for Non-Enzymatic Glucose Sensing with Improved Sensitivity

Lab on a chip for detecting Clara cell protein 16 (CC16) for potential screening of the workers exposed to respirable silica aerosol

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