2015
DOI: 10.1021/acsnano.5b00396
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Abstract: Precise monitoring of the rapidly changing immune status during the course of a disease requires multiplex analysis of cytokines from frequently sampled human blood. However, the current lack of rapid, multiplex, and low volume assays makes immune monitoring for clinical decision-making (e.g., critically ill patients) impractical. Without such assays, immune monitoring is even virtually impossible for infants and neonates with infectious diseases and/or immune mediated disorders as access to their blood in lar… Show more

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Cited by 270 publications
(270 citation statements)
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“…The detection limit was comparable to those achieved previously using an electrochemical device 34 and nanoplasmonic device. 35 On the other hand, the detection limit was higher than that achieved using a silicon photonic sensor and an amplification process comprising an enzymatic reaction product that precipitates on the sensor surface. 36 Moreover, the detection limit was higher, by more than one order of magnitude, than that achieved by the conventional ELISA using the same reagents.…”
Section: ■ Results and Discussionmentioning
confidence: 95%
“…The detection limit was comparable to those achieved previously using an electrochemical device 34 and nanoplasmonic device. 35 On the other hand, the detection limit was higher than that achieved using a silicon photonic sensor and an amplification process comprising an enzymatic reaction product that precipitates on the sensor surface. 36 Moreover, the detection limit was higher, by more than one order of magnitude, than that achieved by the conventional ELISA using the same reagents.…”
Section: ■ Results and Discussionmentioning
confidence: 95%
“…Our recent study 12 has demonstrated a multiplexed immunoassay that allows rapid, high-sensitivity, high-throughput, sample-sparing detection of several different cytokines in human serum using nanoplasmonic biosensor microarrays. This assay involves localized-surface plasmon resonance (LSPR) imaging of biosensors integrated in a microfluidic platform as a key detection principle.…”
mentioning
confidence: 99%
“…More sensitive cytokine assays are now available. (20) While statins are known to reduce inflammation (21), and our findings did not differ by statin use, we may have been underpowered to detect this. Finally, although samples were drawn with regard to menstrual cycling, the role of hormones is not considered in this analysis.…”
Section: Discussion Of the Hypothesismentioning
confidence: 65%