Multiple α subunits of integrin are involved in cell-mediated responses of the Manduca immune system

Effect of 17β-estradiol on adhesion of Mytilus galloprovincialis hemocytes to selected substrates. Role of alpha2 integrin subunit

“…Alpha2 integrin subunit is implicated in cell-mediated immune responses and specifically in interactions between ECM proteins and cells [81,82]. Our results suggest that a 2 integrin subunit is involved in the adhesion process of M. galloprovincialis hemocytes to collagen IV and oxidized collagen IV.…”

A target‐specific feeding toxicity of β1 integrin dsRNA against diamondback moth, Plutella xylostella

“…Drosophila integrins are best characterized in their functional molecular forms and analyzed on their roles in embryonic development, muscle contraction, gut morphogenesis, and interaction with extracellular matrix (Hynes and Zhao, 2000;Brower, 2003). Two lepidopteran insects, Pseudoplusia includens and Manduca sexta, have been shown to express at least three a subunits and one b subunit that may form functional integrin(s) in hemocytes to be implicated in cell aggregation, such as nodule formation or encapsulation (Lavine and Strand, 2003;Zhuang et al, 2008). In fact, integrins of M. sexta have been shown to interact with other cell surface proteins, neuroglian and tetraspanin, to form an encapsulation response of hemocytes upon immune challenge (Zhuang et al, 2007a,b).…”

Genomic scan for identifying candidate genes for paratuberculosis resistance in sheep

“…It is interesting to note that the PRMD1 gene was considered by Minozzi et al (2010) a strong functional candidate of MAP resistance; these authors have, in fact, performed a GWAS in Holstein cows, using the Illumina Bovine SNP50 BeadChip, and have identified SNP on chromosomes 12, 8, 9, 11, and 27 with significant association with MAP antibody response, but reported that the only gene that could be considered a strong functional candidate was PRMD1, a transcription repressor that acts on the b interferon gene expression and affects the maturation of B-lymphocytes into antibody secreting cells. The ITFG2 gene, belonging to the integrin a family, was reported to be involved in cell-mediated responses by Zhuang et al (2008).…”