Multiple tumor-suppressor genes on chromosome 3p contribute to head and neck squamous cell carcinoma tumorigenesis

Lee, Dong Jin; Schönleben, Frank; Banuchi, Victoria E.; Qiu, Wanglong; Close, Lanny Garth; Assaad, Adel; Su, Gloria H.

doi:10.4161/cbt.10.7.12886

Cited by 24 publications

(26 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Accordingly, 42 probsets (32 genes) were over-expressed and 8 probsets (7 genes) were down-regulated. Some were already associated with T-CD8 + leukemias ( Il2ra [5]; and Pdgfrb [6]) and others were associated with other types of T-leukemias or cancer ( Irf4 [7], Hrb [8], Depdc6 [9], Als2cl [10], Tle4 [11] and Cdc42ep3 [12]) (Table 1), thus validating our approach. Interestingly, many other genes were neither associated with leukemias nor with other types of cancer, or had no assigned function representing therefore good candidates as specific markers, oncogenes or tumor suppressors for T-CD8 + leukemias.…”

Section: Resultssupporting

confidence: 72%

“…Some of these genes were already known to be involved in T-CD8 + leukemias: Il2ra (expressed in primary leukemia cells from a patient with T-CD8 + prolymphocytic leukemia) [5]. Our microarray analysis also showed that some other genes were known to be associated with other T-leukemia sub-types or cancer as Irf4 (an oncogene locus which is frequently translocated in peripheral T-cell lymphomas) [7], Depdc6 (when over-expressed, it increases survival of hepatocellular carcinoma cells) [9] and Als2cl (a tumor-suppressor gene that contributes to the tumorigenesis of head and neck squamous cell carcinoma) [10]. These results validate our new microarray analysis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Characterization and identification of PARM-1 as a new potential oncogene

et al. 2013

View full text Add to dashboard Cite

BackgroundThe Graffi murine retrovirus is a powerful tool to find leukemia associated oncogenes. Using DNA microarrays, we recently identified several genes specifically deregulated in T- and B-leukemias induced by this virus.ResultsIn the present study, probsets associated with T-CD8+ leukemias were analyzed and we validated the expression profile of the Parm-1 gene. PARM-1 is a member of the mucin family. We showed that human PARM-1 is an intact secreted protein accumulating predominantly, such as murine PARM-1, at the Golgi and in the early and late endosomes. PARM-1 colocalization with α-tubulin suggests that its trafficking within the cell involves the microtubule cytoskeleton. Also, the protein co-localizes with caveolin-1 which probably mediates its internalization. Transient transfection of both mouse and human Parm-1 cDNAs conferred anchorage- and serum-independent growth and enhanced cell proliferation. Moreover, deletion mutants of human PARM-1 without either extracellular or cytoplasmic portions seem to retain the ability to induce anchorage-independent growth of NIH/3T3 cells. In addition, PARM-1 increases ERK1/2, but more importantly AKT and STAT3 phosphorylation.ConclusionsOur results strongly suggest the oncogenic potential of PARM-1.

show abstract

Section: Resultssupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Characterization and identification of PARM-1 as a new potential oncogene

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Our findings that loss of MLH1 is observed in a significant proportion of our patient cohort is in accordance with the suggestion that a tumor suppressor gene on chromosome 3p might be responsible for oncogenesis in HNSCC . Our data are in agreement with the reports that MLH1 is a candidate tumor suppressor in head and neck cancer and is deleted in a considerable fraction of the tumors .…”

Section: Discussionsupporting

confidence: 93%

Copy number profiling of tumor suppressor genes in head and neck cancer

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Consistent with tumor suppression by EphA3, several reports demonstrate that the EphA3 promoter is silenced by methylation in colorectal cancer, particularly in association with the oncogenic BRAF V600E mutation, and in hematopoietic tumors (68, 69). In addition, the chromosomal region that encompasses the EphA3 gene often undergoes loss of heterozygosity in lung and other cancers (24, 70–73). …”

Section: Discussionmentioning

confidence: 99%

Cancer Somatic Mutations Disrupt Functions of the EphA3 Receptor Tyrosine Kinase through Multiple Mechanisms

2012

View full text Add to dashboard Cite

The Eph receptor tyrosine kinases are an important family of signal transduction molecules that control many cellular processes, including cell adhesion and movement, cell shape and cell growth. All of these are important aspects of cancer progression, but the relationship between Eph receptors and cancer is complex and not fully understood. Genetic screens of tumor specimens from cancer patients have revealed somatic mutations in many Eph receptors. The most highly mutated Eph receptor is EphA3, but its functional role in cancer is currently not well established. Here we show that many EphA3 mutations identified in lung, colorectal and hepatocellular cancers, melanoma and glioblastoma impair kinase activity or ephrin ligand binding and/or decrease receptor cell surface localization. These results suggest that EphA3 has ephrin- and kinase-dependent tumor suppressing activities, which are disrupted by somatic cancer mutations.

show abstract

Multiple tumor-suppressor genes on chromosome 3p contribute to head and neck squamous cell carcinoma tumorigenesis

Cited by 24 publications

References 16 publications

Characterization and identification of PARM-1 as a new potential oncogene

Characterization and identification of PARM-1 as a new potential oncogene

Copy number profiling of tumor suppressor genes in head and neck cancer

Cancer Somatic Mutations Disrupt Functions of the EphA3 Receptor Tyrosine Kinase through Multiple Mechanisms

Contact Info

Product

Resources

About