Multiple trichoepithelioma and breast carcinoma. Simultaneous appearance of epithelioma adenoides cysticum and infiltrating lobular carcinoma of the breast

Sandbank, M.

doi:10.1001/archderm.114.8.1230

Cited by 6 publications

(6 citation statements)

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“…FEP was previously reported in the literature in association with Paget's disease (7), breast cancer (8,9) and, as a variant of BCC, Gorlin-Goltz syndrome (10). However, conclusive epidemiological and biomolecular data on these clinical associations are currently lacking (11,12).…”

Section: Discussionmentioning

confidence: 97%

Fibroepithelioma of Pinkus: Solitary tumor or sign of a complex gastrointestinal syndrome

Longo

Pellacani

Tomasi

et al. 2016

Molecular and Clinical Oncology

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Abstract. Fibroepithelioma of Pinkus (FEP), which is considered to be an uncommon variant of basal cell carcinoma, has been described in association with other systemic diseases. However, no specific studies are currently available on this subject. The aim of our study was to evaluate the clinical and morphological characteristics of FEP and investigate whether this rare tumor is a single entity or seen in the context of a more complex syndrome. We retrospectively analyzed 49 cases of FEP diagnosed and excised in a single academic institution from 1995 to 2011. The tumors were mainly located on the trunk (77.55%), followed by the lower extremities (12.20%) and the head and neck (10.20%). In 9 of the 49 cases (18%), FEP was associated with gastrointestinal tumors. The abovementioned cases are presented in an attempt to make clinicians more aware of a possible association between FEP and gastrointestinal cancer. Although a possible underlying common genetic background between FEP and gastrointestinal tumors was not provided, our study suggests that patients with FEP should be screened for the occurrence of gastrointestinal tumors. IntroductionFibroepithelioma of Pinkus (FEP) is considered to be an uncommon variant of basal cell carcinoma (BCC) (1), although it was recently described as a trichoblastoma (2,3). Clinically, FEP appears as a solitary non-pigmented or brownish to gray, well-outlined flat or polypoid lesion, with peculiar dermoscopic and confocal aspects (4) and with a predilection for the lower trunk (Fig. 1).Histopathologically, FEP is characterized by numerous thin anastomosing cords of basaloid cells extending downward from the epidermis into the dermis within a fibrotic stroma (Fig. 1).Unlike the common types of BCC, FEP exhibits an overwhelming predilection for the trunk (particularly the lower back) and the extremities, with only 5% of the tumors arising on sun-damaged skin. The clinical differential diagnosis includes a wide spectrum of lesions, such as skin tags or dermal nevi. However, the diagnosis is easier when the clinical examination is combined with dermoscopy and confocal microscopy (4,5).Although FEP was originally described by Pinkus as a variant of BCC, the nature of this tumor remains a subject of debate.The strong predilection for the lumbar region (not sun-exposed area) and for the female gender differentiates FEP from other BCC subtypes that usually arise on sun-exposed areas and̸or predominantly in men.Furthermore, FEP exhibits a peculiar histopathological architecture, as well as the presence of Merkel cells, which are usually absent in BCCs but found in trichoblastomas.Thus far, FEP has been described as a solitary lesion or in association with Paget's disease in a limited number of case series. However, no studies have been performed to investigate whether this lesion arises as an isolated rare tumor or in patients harboring specific diseases.The aim of our study was the characterization of a consecutive series of FEPs to identify a possible association of this tumor with con...

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Section: Discussionmentioning

confidence: 97%

Fibroepithelioma of Pinkus: Solitary tumor or sign of a complex gastrointestinal syndrome

Longo

Pellacani

Tomasi

et al. 2016

Molecular and Clinical Oncology

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“…Multiple follicular neoplasia may be asso ciated with internal neoplasms; examples of such associations arc multiple trichoepithe lioma-like tumors and breast carcinoma [14], perifollicular fibromas with colonic polyposis [3] or adenocarcinoma [15], and the multiple trichilemmoma constituting the Cowden's syndrome [ 16], There is no as sociation between the Birt-Hogg-Dube syn drome and internal neoplasia. The original report of Bin et al [4] is about a family with both familial medullary carcinoma of the thyroid and cutaneous lesions, but was re ported as the intermingling of two different inherited traits.…”

Section: Commentmentioning

confidence: 99%

Multiple Fibrofolliculomas and Trichodiscomas

Moreno¹,

Puig

Moragas

1985

Dermatology

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A late-onset, sporadic case of multiple fibrofolliculomas and trichodiscomas is reported. This case and other reports in the literature suggest to the authors that benign neoplasms derived from the mesodermal component of the pilar apparatus may present in various combinations and may also be associated with other hamartomatous skin proliferations. The wide spectrum of published combinations may be due to similarities in clinical presentation and biopsy-sampling uncertainties

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“…There are no regularly associated abnormalities with trichoepitheliomas. However, reports of renal and pulmonary cysts, 6 infiltrating lobular breast carcinoma, 15 carcinoma of the uterine cervix, 16 Ancell‐Spiegler (turban tumor) cylindromas, 17,18 and syringomas 19,20 have been described concurrently in patients with multiple trichoepitheliomas. The occurrence of basal‐cell carcinoma in multiple trichoepitheliomas 21,22 remains controversial 23 …”

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confidence: 99%

Carbon Dioxide (CO₂) Laser Vaporization for the Treatment of Multiple Trichoepithelioma

Wheeland

Bailin

Kronberg

1984

The Journal of Dermatologic Surgery and Oncology

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Multiple trichoepithelioma and breast carcinoma. Simultaneous appearance of epithelioma adenoides cysticum and infiltrating lobular carcinoma of the breast

Cited by 6 publications

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Fibroepithelioma of Pinkus: Solitary tumor or sign of a complex gastrointestinal syndrome

Fibroepithelioma of Pinkus: Solitary tumor or sign of a complex gastrointestinal syndrome

Multiple Fibrofolliculomas and Trichodiscomas

Carbon Dioxide (CO₂) Laser Vaporization for the Treatment of Multiple Trichoepithelioma

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Multiple trichoepithelioma and breast carcinoma. Simultaneous appearance of epithelioma adenoides cysticum and infiltrating lobular carcinoma of the breast

Cited by 6 publications

References 0 publications

Fibroepithelioma of Pinkus: Solitary tumor or sign of a complex gastrointestinal syndrome

Fibroepithelioma of Pinkus: Solitary tumor or sign of a complex gastrointestinal syndrome

Multiple Fibrofolliculomas and Trichodiscomas

Carbon Dioxide (CO2) Laser Vaporization for the Treatment of Multiple Trichoepithelioma

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Product

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Carbon Dioxide (CO₂) Laser Vaporization for the Treatment of Multiple Trichoepithelioma