Multiple trichoblastomas in a dog

Abstract

Trichoblastomas are generally benign but can present as multiple neoplasms that may require surgical resection and may respond to chemotherapy. To the authors' knowledge, this is the first report of multiple trichoblastomas in a dog.

Cytologic features of cutaneous follicular tumors and cysts in dogs

“…Typically, trichoblastomas are benign. In rare occasions, trichoblastomas, trichoepitheliomas, and pilomatricomas have malignant potential or may have aggressive biologic behavior despite their innocuous cytologic appearance . Thus, by narrowing the likely type of follicular tumor to trichoblastoma based on the cytologic features of pink matrix, spindle cells, and clumps of basaloid cells, clinical pathologists can help guide clinicians in deciding whether excision is warranted to assess for potential malignancy.…”

Trichoblastoma in young dog (Canis lupus familiaris) – First Case Report in Mozambique, Africa

“…O tricoblastoma é uma neoplasia benigna cutânea comum em cães e gatos adultos e incomum em cães jovens (Goldschmidt & Hendrick, 2002;Gross et al, 2009;Mineshige et al, 2014;Campos et al, 2014;Kumar et al, 2015). É derivado do folículo piloso primitivo, possuindo componentes epiteliais e mesenquimais, e não é considerado agressivo, porém, existem relatos na literatura de tricoblastomas com características de neoplasia maligna (Gross et al, 2009;Kumar et al, 2015).…”

“…É derivado do folículo piloso primitivo, possuindo componentes epiteliais e mesenquimais, e não é considerado agressivo, porém, existem relatos na literatura de tricoblastomas com características de neoplasia maligna (Gross et al, 2009;Kumar et al, 2015). Cães com idade entre seis e nove anos são os mais acometidos, e não existe predisposição entre machos e fêmeas (Goldschimidt & Hendrick, 2002;Gross et al, 2009, Campos et al, 2014. As raças mais acometidas pelo tricoblastoma são: Poodle, Cocker Spaniel, Kerry Blue Terrier, Wheaton Terrier, Bichonfrisé, Shetland Sheepdog, Husky Siberiano, Aieredale Terrier, English Springer Spaniel, Collie e Yorkshire Terrier (Goldschimidt & Hendrick, 2002;Gross et al, 2009).…”

Immunohistochemical characterisation of a canine case of granular cell type trichoblastoma: a case report

“…Histologically, canine trichoblastoma is divided into four types: ribbon, trabecular, granular and spindle cell. Most cases are a mixture of these patterns with a predominance of ribbon epithelial aggregates surrounded by fibrous stroma (Gross et al 2005;Campos et al 2014). The neoplastic epithelial cells have scant, pale eosinophilic cytoplasm with uniform, ovoid and euchromatic nuclei.…”

“…Mitotic figures are usually infrequent (Gross et al 2005). On immunohistochemical examination, canine and feline trichoblastomas show diffuse staining with the polyclonal reagent 34bE12 (cytokeratins; CKs 1, 5, 10, 11) and relatively strong patchy staining with CK14 (Gross et al 2005;Sakuma et al 2010;Campos et al 2014). In addition, p63, which is used as a basaloid cell marker, is also expressed in trichoblastomas (Saraiva et al 2008, Mineshige et al 2014.…”