Multiple Sclerosis in Taiwan: A Reappraisal

Hung, T.

doi:10.1159/000408031

Cited by 4 publications

(5 citation statements)

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“…In many respects, the Indian series of MS which Singhal and Wadia33 reported and the Japanese series reported by Kuroiwa cl al. 25 were similar to series reported in other parts of the world, for instance, the average age at onset was dose to 30 years, there was a slight female excess of cases, the proportion of severely disabled cases in the series and the spinal fluid findings…”

Section: Clinical Features Of Ms In Different Populationssupporting

confidence: 86%

“…No one value could accurately reflect risk of MS because those who migrated while young, between 1950 and 1969, were still young when the observations were terminated; for example, a person who was 10 years old when he came to Israel in 1950 would be only 30 years old in 1969 and he could still develop MS. Therefore, age-specific incidence of MS among immigrants was calculated for different age-at-immigration cohorts.…”

Section: Immigration and Msmentioning

confidence: 99%

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Clues to the cause based upon the epidemiology of multiple sclerosis

Alter¹

1977

Multiple Sclerosis

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The primary goal of epidemiological research in multiple sclerosis (MS) is to determine the environmental and host factors which are related to the cause of this disease. These factors are sought by analysing MS frequency in different populations and in different parts of the world. Over the last half-century, a large literature has accumulated documenting differences in frequency of MS among peoples and places I -3 and, if reasons for these differences were known, then the list of possible environmental and host factors related to the cause of MS could at least be narrowed. Therefore, the observed differences in MS frequency can provide important clues to aetiology if their meaning were unravelled.One consistent fmding to emerge from epidemiological research in MS is that this disease has an une qual geographical distribution. Since the mid-1950S, it has been known that MS was more common in temperate than in tropical areas of the world4• 5. More recent studies of MS distribution introduced methodological refinements but the general characteristics of the geographical distribution have not been appreciably altered. Today, it is generally accepted that MS increases in frequency with geographicallatitude both in the northern 6 and southern hemisphere7• ReviewsI. 2.8 of the geographical distribution ofMS have been published and Figure 3.1 summarizes some of this information.According to one interpretation9, the geographical distribution of MS resembles a parabolic gradient (Figure 3.2) which increases sharply with latitude. An alternative interpretation IO of these same data is that zones of 35 E. J. Field (ed.), Multiple Sclerosis

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Section: Clinical Features Of Ms In Different Populationssupporting

confidence: 86%

Section: Immigration and Msmentioning

confidence: 99%

Clues to the cause based upon the epidemiology of multiple sclerosis

Alter¹

1977

Multiple Sclerosis

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“…Twenty three (92%) patients developed weakness of the limbs. It is much higher than Germany (43%) 35 , USA (54%) 24 , Japan (24%) 34 and Taiwan (40%) 30 series. This is because that our patients usually presents late in the disease course.…”

Section: Discussionmentioning

confidence: 80%

“…It was 22% in Brazil 38 , 10% in Germany 35 , 30% in the USA 24 , 4% in Taiwan 30 and 23% in Korea 36 .…”

Section: Discussionmentioning

confidence: 97%