Multiple sclerosis and human T-cell lymphotropic retroviruses

Koprowski, Hilary; DeFreitas, Elaine; Harper, Mary‐Ellen; Sandberg‐Wollheim, Magnhild; Sheremata, William A.; Robert-Guroff, Marjorie; Saxinger, Carl; Feinberg, Mark B.; Wong‐Staal, Flossie; Gallo, Robert C.

doi:10.1038/318154a0

Cited by 351 publications

(116 citation statements)

References 29 publications

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“…Our failure to demonstrate serological evidence for exposure to HTLV I and III (HIV) in patients with multiple sclerosis contrasts with the findings of Koprowski et al [5] but is in agreement with more recent results [1,4,7,8]. Although they are regarded as reliable indicators of HTLV exposure in population screening, Koprowski et al [6] suggest that commercial ELISA tests against disrupted virions are insensitive cornOffprint requests to: D. A. S. Compston pared with assays detecting antibody to the major core protein p24 of HTLV I alone because the antibodies are present in low titre, cross-reactive and only present sporadically in the course of the disease.…”

contrasting

confidence: 99%

“…Sirs: It has recently been claimed that a novel retrovirus may be involved in the aetiology of multiple sclerosis [5]. Serological tests have demonstrated antibodies to human T-cell lymphotropic viruses (HTLV) I, II and III (HIV) in up to 70% of patients and molecularly cloned probes have revealed the existence of HTLV-I related nucleotide sequences in cells from the cerebrospinal fluid of some affected individuals.…”

mentioning

confidence: 99%

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Human T-cell lymphotrophic viruses in patients with multiple sclerosis

et al. 1987

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confidence: 99%

Human T-cell lymphotrophic viruses in patients with multiple sclerosis

et al. 1987

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“…In particular, the association of human immunodeficiency virus (HIV) in AIDS encephalopathy and human T-celllymphotropic virus I (HTLV-1) in tropical spastic paraparesis (TSP) has given support to the hypothesis that human retroviruses may also be involved in MS. Moreover, following serological andin situ hybridization studies a possible relationship between HTL V-I related viruses and MS has been suggested [8,13]. However, other investigators obtained negative results and could not confirm this association (5,7].…”

Section: Introductionmentioning

confidence: 99%

Search for retroviral sequences in peripheral blood mononuclear cells and brain tissue of multiple sclerosis patients

et al. 1990

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Summary.DNAs from peripheral blood mononuclear cells (PBMCs) of 21 patients with multiple sclerosis (MS), 1 patient with tropical spastic paraparesis (TSP) as well as DNAs from brain and spinal cord of 5 MS cases and 3 controls were examined for human T-cell lymphotropic virus (HTLV)-related sequences by polymerase chain reaction. The primers used were derived from the HTLV-1 gag, env and tax genes. Amplified products were separated on agarase gels, blotted onto nylon membranes and hybridized to specific radiolabelled oligonucleotides. The sensitivity of amplification_ and hybridization was one copy of target DNA in 10' cellular genomes. None of the specimens was positive for HTLV-1 sequences except the TSP probe. These negative data are all the more significant because brain -material from MS patients was used in these studies. Our studies thus fail to support speculations that HTLV-I is involved in the aetiology of multiple sclerosis.

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“…The seven cases of MS associated with male HD patients included a mother, two fathers (one of whom also had a sister with MS), the remainder being relatives by marriage rather than direct blood relatives. Recent evidence has implicated an (as yet) unidentified retrovirus in MS (Koprowski et al, 1985).…”

Section: Past Medical Historymentioning

confidence: 99%

Hodgkin's disease: case control epidemiological study in Yorkshire

Bernard¹,

Cartwright²,

Darwin³

et al. 1987

Br J Cancer

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Summary This is the first report of a case-control epidemiological study on lymphomas and leukaemias occurring in Yorkshire during 1979-84. This paper deals with the results of the Hodgkin's disease analysis comprising 248 cases and 489 controls. The results indicate support for previous work with respect to small family size and past history of infectious mononucleosis. Positive observations made in a previous pilot study are also confirmed and extended with respect to associations with certain chronic skin lesions, dental anaesthesia and familial factors. Negative associations are described with respect to X-ray exposures and cigarette smoking. It is proposed that these results fit into a general hypothesis that these conditions are the result of interaction between infectious agents and altered immunity in those persons genetically predisposed. the control group but the majority of controls were in hospital either due to an accident or for cold surgery. All interviews were conducted by trained interviewers, usually in hospital, using a standard questionnaire covering all aspects of past life relating to occupation, hobbies, personal habits, drug ingestion, family history and past medical history. Hospital and GP records were checked to confirm the accuracy of drug and medical histories. Cancer in other blood relatives was also cross-checked with the cancer registries or by death certificate perusal. All data were coded, computerised and validated by a trained group not involved with interviewing. The case-control statistics were produced using the programmes of Rothman and Boice (1979), using their stratified techniques.Two levels of analysis were undertaken: firstly, by pooling age groups, disease subtype and sex; and, secondly, by stratifying where possible by sex, age (15-35yr vs. 36+yr of age), and subtypes of disease. Results Cases studiedThe total number of HD cases occurring in the Region during the period exceeded that interviewed. The pilot study used the same data base but its results are independent of the analyses presented here. Non-significant or unassessable risk Some topics could not be studied adequately because the number of case or control responses was too small. Table I lists topics with 5 or less eligible cases and controls, which are not considered further. Table II shows non-significant differences at the 5% level of probability, having computed risk ratios less than 2.0. A few factors with higher risk ratios, which are not statistically significant in the pooled data, include the occupation of hand and machine sewers Br.

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Multiple sclerosis and human T-cell lymphotropic retroviruses

Cited by 351 publications

References 29 publications

Human T-cell lymphotrophic viruses in patients with multiple sclerosis

Human T-cell lymphotrophic viruses in patients with multiple sclerosis

Search for retroviral sequences in peripheral blood mononuclear cells and brain tissue of multiple sclerosis patients

Hodgkin's disease: case control epidemiological study in Yorkshire

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