Multiple sclerosis and gluten sensitivity

Nutrition in multiple sclerosis

“…The other association was gluten sensitivity and MS. It has been proposed that antigliadin antibodies have a role in MS and although some studies have found elevated levels of these antibodies, differences were not significant (28)(29)(30).…”

A Case of Multiple Sclerosis and Celiac Disease

“…Since gluten sensitivity and serum antigliadin (AGA), antiendomysium (AEA), and antitissue transglutaminase (AtTGA) antibodies had been studied in MS patients, most of the studies found the prevalence of antigliadin antibodies in MS patients was the same as in controls [1, 6–9]. On the other hand, CD presents neurological dysfunctions like ataxia, peripheral neuropathy, and epilepsy.…”

“…MS, resembling other autoimmune disorders, has a multifactorial etiology, including environmental, immunological, and genetic factors. MS is sometimes difficult to be differentiated from CNS involvement in systemic autoimmune diseases [1]. …”

Gluten‐Free Diet in Nonceliac Disease

“…Historically, a GFD was occasionally used in the management of multiple sclerosis (MS), because anecdotal reports indicated a positive effect (reversal of symptoms) of a GFD in MS patients. 63 , 64 However, there is no evidence of an increase in prevalence of gluten sensitivity in patients with relapsing‐remitting or secondary‐progressive MS. 65 , 66 Patients with relapsing‐remitting MS, secondary‐progressive MS, or both have a prevalence of antigliadin antibodies of 10%, similar to the healthy population (12.5%) 67 . Brain MRI in patients with a gradually progressive neurologic disease and gluten sensitivity showed lesions of the white matter, indistinguishable from those in MS patients, but these patients can also have neurophysiologic evidence of an axonal peripheral neuropathy that distinguishes them from primary‐progressive MS patients.…”