Multiple Sclerosis After Infectious Mononucleosis

Abstract

Background: Infectious mononucleosis caused by the Epstein-Barr virus has been associated with increased risk of multiple sclerosis. However, little is known about the characteristics of this association.Objective: To assess the significance of sex, age at and time since infectious mononucleosis, and attained age to the risk of developing multiple sclerosis after infectious mononucleosis.

Health-related quality of life of relapsing or remitting multiple sclerosis patients: A case-control study

“…In contrast with other studies that have suggested a higher risk of MS associated with a family history of MS [27], shift work [28], infectious mononucleosis [10], childhood and adolescent obesity [29,30], we did not observe any role of these variables in predicting the risk of MS. Our results may not truly indicate the effect of infectious mononucleosis on the risk of MS because we relied on the memory of patients in this question without performing the confirmation test. Moreover, this study showed that several socio-demographic, lifestyle, and clinical characteristics were significant predictors of HRQoL.…”

Health-related quality of life of relapsing or remitting multiple sclerosis patients: A case-control study

“…In contrast with other studies that have suggested a higher risk of MS associated with a family history of MS [27], shift work [28], infectious mononucleosis [10], childhood and adolescent obesity [29,30], we did not observe any role of these variables in predicting the risk of MS. Our results may not truly indicate the effect of infectious mononucleosis on the risk of MS because we relied on the memory of patients in this question without performing the confirmation test. Moreover, this study showed that several socio-demographic, lifestyle, and clinical characteristics were significant predictors of HRQoL.…”

Association of Infectious Mononucleosis in Childhood and Adolescence With Risk for a Subsequent Multiple Sclerosis Diagnosis Among Siblings

“…The waning of IM-associated risk for MS after adolescence is consistent with other research . Our results suggest that childhood and in particular adolescence seem to be periods when acute IM is relevant to MS risk.…”

“…The waning of IM-associated risk for MS after adolescence is consistent with other research. 16 Our results suggest that childhood and in particular adolescence seem to be periods when acute IM is relevant to MS risk. Such an age-specific pattern is consistent with prior research on other environmental risk factors, in which some exposures seem to have greater consequences in adolescence than in earlier childhood, 27 including hospital-diagnosed infections other than EBV or IM.…”

A population-based case–control study on viral infections and vaccinations and subsequent multiple sclerosis risk

“…The results of a large population-based case-control study in the Netherlands showed significant differences, but these were reported to be eliminated when a correction was applied for an estimated recall bias [34]. Our findings of equal frequency of infections in MS patients and controls, and of a twofold higher MS risk associated with infectious mononucleosis agree with the findings in other studies [35,36].…”

Health-related quality of life of relapsing or remitting multiple sclerosis patients: A case-control study

“…In contrast with other studies that have suggested a higher risk of MS associated with a family history of MS [27], shift work [28], infectious mononucleosis [10], childhood and adolescent obesity [29,30], we did not observe any role of these variables in predicting the risk of MS. Our results may not truly indicate the effect of infectious mononucleosis on the risk of MS because we relied on the memory of patients in this question without performing the confirmation test. Moreover, this study showed that several socio-demographic, lifestyle, and clinical characteristics were significant predictors of HRQoL.…”

Association of Infectious Mononucleosis in Childhood and Adolescence With Risk for a Subsequent Multiple Sclerosis Diagnosis Among Siblings

“…The waning of IM-associated risk for MS after adolescence is consistent with other research . Our results suggest that childhood and in particular adolescence seem to be periods when acute IM is relevant to MS risk.…”

“…The waning of IM-associated risk for MS after adolescence is consistent with other research. 16 Our results suggest that childhood and in particular adolescence seem to be periods when acute IM is relevant to MS risk. Such an age-specific pattern is consistent with prior research on other environmental risk factors, in which some exposures seem to have greater consequences in adolescence than in earlier childhood, 27 including hospital-diagnosed infections other than EBV or IM.…”

A population-based case–control study on viral infections and vaccinations and subsequent multiple sclerosis risk

“…The results of a large population-based case-control study in the Netherlands showed significant differences, but these were reported to be eliminated when a correction was applied for an estimated recall bias [34]. Our findings of equal frequency of infections in MS patients and controls, and of a twofold higher MS risk associated with infectious mononucleosis agree with the findings in other studies [35,36].…”

Health-related quality of life of relapsing or remitting multiple sclerosis patients: A case-control study

“…In contrast with other studies that have suggested a higher risk of MS associated with a family history of MS [27], shift work [28], infectious mononucleosis [10], childhood and adolescent obesity [29,30], we did not observe any role of these variables in predicting the risk of MS. Our results may not truly indicate the effect of infectious mononucleosis on the risk of MS because we relied on the memory of patients in this question without performing the confirmation test. Moreover, this study showed that several socio-demographic, lifestyle, and clinical characteristics were significant predictors of HRQoL.…”

Association of Infectious Mononucleosis in Childhood and Adolescence With Risk for a Subsequent Multiple Sclerosis Diagnosis Among Siblings

“…The waning of IM-associated risk for MS after adolescence is consistent with other research . Our results suggest that childhood and in particular adolescence seem to be periods when acute IM is relevant to MS risk.…”

“…The waning of IM-associated risk for MS after adolescence is consistent with other research. 16 Our results suggest that childhood and in particular adolescence seem to be periods when acute IM is relevant to MS risk. Such an age-specific pattern is consistent with prior research on other environmental risk factors, in which some exposures seem to have greater consequences in adolescence than in earlier childhood, 27 including hospital-diagnosed infections other than EBV or IM.…”

A population-based case–control study on viral infections and vaccinations and subsequent multiple sclerosis risk

“…The results of a large population-based case-control study in the Netherlands showed significant differences, but these were reported to be eliminated when a correction was applied for an estimated recall bias [34]. Our findings of equal frequency of infections in MS patients and controls, and of a twofold higher MS risk associated with infectious mononucleosis agree with the findings in other studies [35,36].…”