Multiple roles of baicalin and baicalein in the regulation of colorectal cancer

Abstract

The prevalence of colorectal cancer is increasing worldwide, and despite advances in treatment, colorectal cancer (CRC) remains in the top three for mortality due to several issues, including drug resistance and low efficiency. There is increasing evidence that baicalin and baicalein, novel small molecule inhibitor extracts of the Chinese herb Scutellaria baicalensis, have better anti-colorectal cancer effects and are less likely to induce drug resistance in cancer cells. The present review article explains the anti-proliferative properties of baicalin and baicalein in the context of against CRC. Additionally, it explores the underlying mechanisms by which these compounds modulate diverse signaling pathways associated with apoptosis, cell proliferation, tumor angiogenesis, invasion, metastasis, and tumor microenvironment. Moreover, this review article highlights the inhibitory effect of colorectal inflammatory-cancer transformation and the near-term therapeutic strategy of using them as adjuvant agents in chemotherapy.

Baicalin and Baicalein Enhance Cytotoxicity, Proapoptotic Activity, and Genotoxicity of Doxorubicin and Docetaxel in MCF-7 Breast Cancer Cells

“…Based on recent research findings [ 41 , 42 , 43 , 44 , 45 , 46 , 47 ], a hypothetical scheme ( Figure 14 ) has been proposed to demonstrate cellular and molecular targets of docetaxel and doxorubicin, as well as baicalin and baicalein, in relation to their anticancer activity. While doxorubicin targets DNA replication and docetaxel disrupts microtubule dynamics, baicalin and baicalein act through a more complex network of cellular processes.…”