Multiple Primary Malignant Neoplasms in Urologic Patients

Abstract

One hundred and four patients with multiple primary malignant neoplasm (MPN) with at least one genitourinary organ involved were analyzed. The 104 patients represented 0.9% of all cancer patients and 9.0% of all urologic tumor cases. Tumors of the prostate and bladder in urologic cancers and tumors of the gastrointestinal tract, particularly stomach cancer, in non-urologic cancers were predominantly involved. In 79 cases (76.0%), the second tumors were discovered within 5 years from the diagnosis of the first cancer. Renal cell carcinoma tended to be discovered incidentally and concomitantly. In contrast, bladder cancer tended to be an initial primary tumor presenting with symptoms, and tumor of prostate tended to be found incidentally, as a second cancer in metachronous cancer associations. All second tumors of the liver were found incidentally with ultrasonographic examination after a small interval. Strict follow-up at regular intervals at least the initial 5 years are essential for the detection of second malignant neoplasms.

Incidence and Prognostic Significance of Second Primary Cancers in Renal Cell Carcinoma

“…Rabbani et al also reported that the papillary type of RCC is associated with a significantly increased risk of second cancers in the prostate and bladder 13 . Other smaller studies have reported that the most common sites for second primary cancers in RCC are the prostate, colon and urinary bladder 22;23 . While second cancers in the bladder accounted for 6.4% of all SPCs in our study (Table 1), the risk was significant only in patients aged 60 years or more (at time of diagnosis of either RCC or the SPC), with RCCs ≤5cm in size and in patients without a history of radiation therapy (Table 3).…”

Metachronous Occurrence of Triple Malignancies of Kidneys, Prostate, and Breast. A Case Report and Review of The Literature

“…Koyama et al [11] studied 104 patients with multiple primary tumors and found an incidence of multiple tumor occurrences of 9% in patients with primary urologic tumors. He found a predominant occurrence of prostate and bladder cancers in urologic cancers and stomach cancer in nonurologic cancers.…”

Renal tumors and second primary pancreatic tumors: a relationship with clinical impact?

“…Patients with a RCC have a significantly higher risk of other subsequent primary malignancies [6,24]. While prevalence studies based on autopsy series have identified a 30% to 40% incidence of other primary malignancies in RCC patients, cohort studies have identified rates of 4.5 to 27.4% [6,7].…”

“…While prevalence studies based on autopsy series have identified a 30% to 40% incidence of other primary malignancies in RCC patients, cohort studies have identified rates of 4.5 to 27.4% [6,7]. A study by Czene et al clearly indicates that patients with RCC are at increased risk of other cancers not only the first year after primary diagnosis, but also after more than 10 years [28].…”

“…The frequency of pancreatic cancer in association with cancer of other organs is estimated to range from 1% to as high as 20% [4], with malignancies predominately of the stomach, colon, thyroid, and genitourinary tract [5]. Second malignancies reported to be associated with renal cell carcinoma (RCC) include Non-Hodgkin’s lymphoma, multiple myeloma, chronic lymphatic leukaemia, melanoma and cancers of the bladder, prostate, breast, rectum, and lung with an incidence that varies from 5 to 27% [6,7]. There has only been infrequent reporting of synchronous or metachronous tumors of the pancreas and the kidney [5,7,8].…”