Multiple primary cutaneous plasmacytomas

Primary cutaneous plasmacytoma: a role for a triggering stimulus?

“…In summary, local pro‐inflammatory stimuli may be a contributing factor in the development of PCP. Six reported cases, including the current case are summarized in Table 1 5,11–14 . Our case demonstrates that plasma cells in PCP are bcl‐2 positive, thus supporting the hypothesis for a HSV‐1/TLR/IL‐6/bcl‐2‐mediated pathway in the pathogenesis of PCP.…”

Primary cutaneous plasmacytoma in an HIV‐positive patient

“…These treatment modalities decrease lesion size, spread, and recurrence when they are used together or as single agents . Patients with multiple lesions or lesions that carry risk factors for recurrence can be treated with more aggressive options, such as chemotherapy . Risk factors for a poor prognosis include multiple lesions, tumor size > 5 cm, IgA‐secreting tumors, and a compromised immune system .…”

“…Green et al . suggested using a combination of chemotherapy and cryopreservation of unaffected bone marrow for patients presenting with high‐risk factors for a poor prognosis or conversion to multiple myeloma in the future.…”

Primary cutaneous plasmacytoma: a clinicopathological study of two cases with a long‐term follow‐up and review of the literature

“…Clinically, PCP is typified by solitary or multiple (up to 50) reddish to purple nodules or plaques with no predilection site. Ulceration of the lesions is rarely observed 8–13 . Histologically, PCP is characterized by a diffuse or nodular, nonepidermotropic infiltrate of plasma cells with various degrees of maturation and pleomorphism.…”