Multiple primary cutaneous melanomas

Beardmore, Graeme L.

doi:10.1001/archderm.111.5.603

Cited by 24 publications

(24 citation statements)

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“…The need for early diagnosis of melanoma is well accepted, but may lose impact in well‐informed populations 34 . Other investigators were unable to detect second melanomas in earlier stages than the primary tumor 35 or found even an increase in tumour thickness 36 . In three of our patients the second melanoma was detected within 1 month after the primary diagnosis.…”

Section: Discussioncontrasting

confidence: 68%

Second malignancies in melanoma patients in Thuringia

Wolff

Wollina

2000

Acad Dermatol Venereol

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Section: Discussioncontrasting

confidence: 68%

Second malignancies in melanoma patients in Thuringia

Wolff

Wollina

2000

Acad Dermatol Venereol

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“…While a significant correlation between their sites has not been reported in most studies, 8, 10, 14, 16, 20, 22, 40 several studies 19, 34, 39 did find site concordance ranging between 52% and 56%. Some degree of site concordance between melanomas in the same patient would be expected because the same patterns of sun exposure and sun protection underlie the occurrence of both lesions.…”

Section: Discussionmentioning

confidence: 85%

Clinicopathologic Features of Incident and Subsequent Tumors in Patients with Multiple Primary Cutaneous Melanomas

et al. 2011

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Background 0.6–12.7% of patients with primary cutaneous melanoma will develop additional melanomas. Pathologic features of tumors in patients with multiple primary cutaneous melanomas have not been well described. In this large international multi-center case-control study, we compared the clinicopathologic features of a subsequent melanoma with the preceding (usually the first) melanoma in patients with multiple primary cutaneous melanomas, and with those of melanomas in patients with single primary cutaneous melanomas. Methods Multiple primary melanoma (cases) and single primary invasive melanoma (controls) patients from the Genes, Environment and Melanoma (GEM) study were included if their tumors were available for pathologic review and confirmed as melanoma. Clinicopathologic characteristics of invasive subsequent and first melanomas in cases and invasive single melanomas in controls were compared. Results 473 pairs comprising a subsequent and a first melanoma and 1989 single melanomas were reviewed. Forward stepwise regression modeling in 395 pairs with complete data showed that, compared to first melanomas, subsequent melanomas were: more commonly contiguous with a dysplastic nevus; more prevalent on the head/neck and legs than other sites; and thinner. Compared with single primary melanomas, subsequent melanomas were also more likely to be: associated with a contiguous dysplastic nevus; more prevalent on the head/neck and legs; and thinner. The same differences were observed when subsequent melanomas were compared with single melanomas. First melanomas were more likely than single melanomas to have associated solar elastosis and no observed mitoses. Conclusions Thinner subsequent than first melanomas suggest earlier diagnosis, perhaps due to closer clinical scrutiny. The association of subsequent melanomas with dysplastic nevi is consistent with the latter being risk factors or risk markers for melanoma.

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“…in 1952 3 . Its frequency has ranged from 1.2% to 8.2% in several series 4–19 . In some cases, the occurrence of multiple primary melanomas may have a genetic background and may be associated with a family history of melanoma.…”

Section: Introductionmentioning

confidence: 99%

The importance of self‐examination in the earliest diagnosis of multiple primary cutaneous melanomas: a report of 47 cases

Manganoni¹,

Farisoglio²,

Tucci³

et al. 2007

Acad Dermatol Venereol

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The study confirms that second primary melanoma is usually thinner than the first lesion, and it is more common in the same region of the body as the initial melanoma. The highest risk for a second melanoma is during the first 5 years, but a much longer time interval of 28 years is possible. Continued medical follow-up with complete skin examinations seems prudent, but it is very important to promote self-skin evaluation in patients to detect not only metastases but also subsequent primary melanomas in their earliest phases.

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Multiple primary cutaneous melanomas

Cited by 24 publications

References 0 publications

Second malignancies in melanoma patients in Thuringia

Second malignancies in melanoma patients in Thuringia

Clinicopathologic Features of Incident and Subsequent Tumors in Patients with Multiple Primary Cutaneous Melanomas

The importance of self‐examination in the earliest diagnosis of multiple primary cutaneous melanomas: a report of 47 cases

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