Multiple primary cancers: An enigma

Jena, Amitabh; Patnayak, Rashmi; Lakshmi, AY; Banoth, Manilal; Reddy, Munish

doi:10.4103/2278-330x.179698

Cited by 37 publications

(47 citation statements)

References 16 publications

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“…In particular, the presence of multiple or double cancers influences the selection and results of treatment modalities for oral cancer (16,18,23,24). In the present study, ~10% of all patients developed multiple cancers, including oral cancer.…”

Section: Discussionmentioning

confidence: 81%

Clinical features of multiple primary carcinomas of the oral cavity

Li¹,

Ma²,

Han³

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. The present study aimed to elucidate the clinical characteristics of multiple primary carcinomas of the oral cavity. The clinical records of 1,024 patients who were treated during follow-up for oral cancer at the Department of Stomatology, Henan Provincial People's Hospital, between March 2013 and December 2014 were retrospectively reviewed. The clinical characteristics of 961 patients who developed single primary oral squamous cell carcinoma (SCC) during follow-up and 54 patients who subsequently developed multiple primary carcinomas in the oral cavity were compared. Multiple primary carcinomas exhibited a female predilection, were most prevalent in the gingiva, and tended to show earlier tumor and nodal stages, as compared with single primary carcinomas. The local recurrence rate was higher for multiple primary carcinomas, as compared with single primary carcinomas, and was demonstrated to increase with the number of multiple primary occurrences. The cumulative incidence rates for metachronous second primary carcinomas following the onset of the first carcinoma at 10 years was 8.0%. Recurrence of multiple primary carcinomas did not decrease the survival rates of the patients assessed in the present study. Furthermore, differences were detected in the clinical characteristics between patients with single oral SCC and those with multiple primary oral carcinomas. The results of the present study indicated that early diagnosis and treatment and close long-term follow-up are required for patients with multiple primary oral carcinomas.

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Section: Discussionmentioning

confidence: 81%

Clinical features of multiple primary carcinomas of the oral cavity

Li¹,

Ma²,

Han³

et al. 2016

Experimental and Therapeutic Medicine

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“…Radiotherapy has also been related to LC risk [2], and breast radiotherapy is an important component of the BC treatment algorithm [37]. A minority of BC patients treated with adjuvant radiotherapy were found to be at risk of developing radiation-induced solid tumors and myeloid neoplasms [38].…”

Section: Discussion/conclusionmentioning

confidence: 99%

“…Furthermore, cancer survivors may be especially susceptible to developing an SPM due to the effects of therapy for their first cancer [2]. LC accounts for 5-18% of SPM and most commonly occurs metachronously as the second cancer [1,18].…”

Section: Discussion/conclusionmentioning

confidence: 99%

“…According to the Surveillance, Epidemiology, and End Results (SEER) database, 8.1% of cancer patients in the US developed an SPM; overall, the lung was the most common SPM site [1]. Recently, there has been an increase in the number of patients diagnosed with SPM [2]. There is a clear need for a better understanding of the molecular, environmental, and clinical factors underlying SPM development.…”

Section: Introductionmentioning

confidence: 99%

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A Single-Center Retrospective Study of Patients with Double Primary Cancers: Breast Cancer and <b><i>EGFR</i></b>-Mutant Non-Small Cell Lung Cancer

et al. 2019

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Background: Second primary malignancies (SPM) in the lung are not common in breast cancer (BC) patients. EGFR-mutant lung cancer (LC) is a separate molecular subset, and the co-existence of EGFR-mutant LC and BC has not been explored. We hypothesized that EGFR-mutant LC patients could have higher rates of primary BC than those with EGFR-wild type (WT). Methods: We collected data on clinical and molecular characteristics and outcomes of female patients with LC and a previous or simultaneous history of primary BC treated in our hospital from 2008 to 2014. Results: Data on treatment, follow-up, and EGFR mutation status were available for 356 patients. 17.7% (11/62) of patients with EGFR mutations had BC, compared to 1.02% (3/294) of EGFR-WT patients (p < 0.001). Both tumors were metachronous in 81.8%, with LC diagnosed 9 years after the diagnosis of BC. 5 of the 6 (83.3%) BC patients treated with radiotherapy developed LC in an area within the radiation field. No EGFR mutations were detected in BC tissue and no HER2 expression was detected in LC samples. Conclusion: SPM in the lung and breast occur more frequently among EGFR-mutant compared to EGFR-WT LC patients. Radiotherapy for BC may increase the risk of developing primary LC.

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“…The patient burden of multiple primary cancers (MPC) has been increasing worldwide. [1][2][3] The increase in the incidence of MPC has also been considered to be related to several factors. The risks of developing cancer were generally higher in the elderly (over 65 years old) than in young adults.…”

Section: Introductionmentioning

confidence: 99%

Multiple primary cancers associated with endometrial and ovarian cancers: An analysis based upon the Japan Autopsy Annual Database from 2002 to 2010

Miki

Sugawara

Shibahara

et al. 2019

J of Obstet and Gynaecol

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Aim A thorough analysis of multiple primary cancers (MPC) could provide important information as to the pathogenesis of human malignancies. Analysis of MPC using clinical databases has been performed, but little has been done using autopsy cases. Therefore, in this study, we first retrospectively analyzed MPC associated with endometrial and ovarian cancers using the Japan Autopsy Annual Database. Methods The Japan Autopsy Annual Database from 2002 to 2010 was established by the Japanese Society of Pathology, Tokyo, Japan. Among the 164 211 autopsy cases registered, 9142 were cases of primary cancers. Results The patients with endometrial cancer‐associated MPC did have a lower risk of harboring colorectal cancer (odds ratio [OR], 0.63; 95% confidence interval [CI], 0.45–0.89) but had a higher risk of ovarian cancer (OR, 3.15; 95% CI, 2.11–4.71). Those with ovarian cancer‐associated MPC had a lower risk of harboring gallbladder cancer including bile ductal cancer (OR, 0.47; 95% CI, 0.27–0.80) but a higher risk of harboring breast (OR, 1.69; 95% CI, 1.20–2.38) and endometrial cancers (OR, 3.48; 95% CI, 2.33–5.20). Conclusion Both endogenous and exogenous factors are associated with the incidence of MPC. Results of our present study based on Japanese Autopsy Base first demonstrated that female hormones had a strong influence on the incidence of MPC. This study also demonstrated that the analysis of MPC using an autopsy database could have advantages over clinical database analysis.

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Multiple primary cancers: An enigma

Cited by 37 publications

References 16 publications

Clinical features of multiple primary carcinomas of the oral cavity

Clinical features of multiple primary carcinomas of the oral cavity

A Single-Center Retrospective Study of Patients with Double Primary Cancers: Breast Cancer and <b><i>EGFR</i></b>-Mutant Non-Small Cell Lung Cancer

Multiple primary cancers associated with endometrial and ovarian cancers: An analysis based upon the Japan Autopsy Annual Database from 2002 to 2010

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