2010
DOI: 10.1111/j.1369-1600.2010.00263.x View full text |Buy / Rent full text
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Abstract: Environmental factors such as stress influence both the predisposition to and development of alcoholism, as well as have significant implications for alcoholism relapse. One predominant biological response to acute stress is the release of norepinephrine, which activates the peripheral stress response and also the hypothalamic-pituitary-adrenal axis. We aimed to examine the role of two genes of the adrenergic system (SLC6A2 and ADRA2A) in alcoholism by genotyping 21 SNPs in 785 adult alcohol-dependent patients… Show more

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“…This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. There is an extensive literature on the gene and many findings suggesting association to ADHD (e.g., Kim et al, 2010; Roman et al, 2005; Roman et al, 2003; Waldman et al, 2006), as well as metabolic traits (e.g., glycemic phenotypes, blood pressure) (for meta-analysis see Talmud et al, 2011) and substance abuse (Clarke et al, 2012; Merenakk et al, 2011; Prestes et al, 2007). Given the neurobiological implications, this gene should be considered a strong candidate in future alcohol abuse studies.…”
Section: Discussionmentioning
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rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. There is an extensive literature on the gene and many findings suggesting association to ADHD (e.g., Kim et al, 2010; Roman et al, 2005; Roman et al, 2003; Waldman et al, 2006), as well as metabolic traits (e.g., glycemic phenotypes, blood pressure) (for meta-analysis see Talmud et al, 2011) and substance abuse (Clarke et al, 2012; Merenakk et al, 2011; Prestes et al, 2007). Given the neurobiological implications, this gene should be considered a strong candidate in future alcohol abuse studies.…”
Section: Discussionmentioning
“…Research has amply demonstrated that both genetic and environmental factors contribute to the development of these disorders [1][5]. The psychoactive effects of alcohol are mediated through its influence on different functional systems in the brain, including the dopamine, serotonin, gamma-aminobutyric acid, glutamate, and opioid peptide systems.…”
Section: Introductionmentioning
“…SLC6A2 SNPs rs36020 and rs36029 that were associated with alcoholism [67], and the loss-of-function ADRA2B indel rs28365031 polymorphism which was shown to increase the availability of noradrenaline [68], were not included in the current study.…”
Section: Discussionmentioning