Multiple palmar basal cell epitheliomas in basal cell nevus syndrome

Early‐onset acral basal cell carcinomas in Gorlin syndrome

“…Sun exposure does not seem to have played any role because of their age and the absence of lesions on their faces; furthermore, the dorsum of feet or the palms are not areas of increased sun exposure. The acral distribution of BCCs in our patients is unusual in GS, as is the presence of palmar BCCs . Although we did not biopsy palmar papules in our patients, they had a very similar appearance to the dorsal papules, and they did not show a pitted appearance of typical palmar pits of GS.…”

Palmar pits associated with the nevoid basal cell carcinoma syndrome

“…2 Two cases of multiple BCC arising in the palmar pits of a nevoid BCC syndrome patient have also been described. 4,5 Most studies attempting to characterize palmoplantar pits occurred in the 1970s using electron microscopy and histochemical stains. Some authors hypothesized, based upon ultrastructural and histochemical findings, that palmoplantar pits might represent 'basal cell epithelioma in situ'.…”

“…A second case series of 17 pits included two examples of BCC . Two cases of multiple BCC arising in the palmar pits of a nevoid BCC syndrome patient have also been described …”