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“…For the third and second stimulations before the second arrow the E frequency was raised to 100 and 150/sec, respectively. a similar type of block was observed also by Brockman & Burson (1957) on the crayfish opener muscle. All the blocking effects of these high concentrations of L-glutamic acid were reversed by washing the preparation free from the compound.…”
Section: Molecular Structure and Inhibitory Effectsupporting
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rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…For the third and second stimulations before the second arrow the E frequency was raised to 100 and 150/sec, respectively. a similar type of block was observed also by Brockman & Burson (1957) on the crayfish opener muscle. All the blocking effects of these high concentrations of L-glutamic acid were reversed by washing the preparation free from the compound.…”
Section: Molecular Structure and Inhibitory Effectsupporting
“…Jouany et al (1960) reported that sodium 4-hydroxybutyrate protected mice against convulsions due to strychnine but we could find no evidence to support this observation. McLennan (1957) reported that y-aminobutyric acid administered subcutaneously protected mice against convulsions due to strychnine but no such action was observed in the present work or by Elliott & Hobbiger (1959) or by Brockman & Burson (1957). From these comparisons it appears probable that sodium 4-hydroxybutyrate and y-aminobutyric acid have similar modes of action on spinal reflexes and that these are different from that, of meprobamate.…”
Section: Discussioncontrasting
“…Hayashi & Nagai (1956) reported that GABA, applied directly to the cortex or injected into the carotid artery, inhibits electrically or chemically induced convulsions in dogs, and McLennan (1956) found that GABA protected mice against fatal strychnine convulsions for a period of 5-10 min. On the other hand Brockman & Burson (1957) were unable to protect mice against a lethal dose of strychnine given 5 min after an intraperitoneal injection of GABA. Purpura, Girado & Grundfest (1957a, b) and Iwama & Jasper (1957) showed that topically applied GABA reverses surface negative post-synaptic potentials of the apical dendrites evoked by various stimuli in the cerebral cortex of unanaesthetized cats.…”
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