2011
DOI: 10.1111/j.1365-2133.2010.10121.x
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Multiple miliary osteoma cutis is a distinct disease entity: four case reports and review of the literature

Abstract: MMOC is a rare but distinct disease entity of unknown aetiology. Histologically, the tiny nodular osteomas show intramembranous superficial ossification but the aetiology appears to be different from GNAS-related disorders. The osteomas seem to increase slowly in number after appearing in middle age.

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Cited by 27 publications
(46 citation statements)
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“…Correlative full-thickness dermatopathology on asymptomatic patients was clearly not possible; thus, we relied on our coauthors' prior large postmortem case series. Some studies suggested the history of severe adolescent acne as a potential precursor of miliary osteoma cutis, 4,7,10,12 but this was not formally evaluated in our retrospective, informed-consent-waived study. In addition, because benign breast skin calcification is thought to be secondary to sebaceous inspissations and low-grade infection, one can only speculate that the idiopathic, primary formation of these nodules may be secondary to subclinical or low-grade inflammatory, infectious, traumatic, or environmental insults.…”
Section: Figmentioning
confidence: 99%
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“…Correlative full-thickness dermatopathology on asymptomatic patients was clearly not possible; thus, we relied on our coauthors' prior large postmortem case series. Some studies suggested the history of severe adolescent acne as a potential precursor of miliary osteoma cutis, 4,7,10,12 but this was not formally evaluated in our retrospective, informed-consent-waived study. In addition, because benign breast skin calcification is thought to be secondary to sebaceous inspissations and low-grade infection, one can only speculate that the idiopathic, primary formation of these nodules may be secondary to subclinical or low-grade inflammatory, infectious, traumatic, or environmental insults.…”
Section: Figmentioning
confidence: 99%
“…It is reported as "miliary osteoma cutis of the face." 4,10,12,13 Current literature agrees on its idiopathic etiology and its benign, noninvasive, and asymptomatic nature. 4,6,10,12,13 However, there have been varying reports regarding its epidemiology.…”
mentioning
confidence: 96%
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“…Miliary osteoma cutis is a rare entity, with just over 50 cases described in the literature [1]. It is characterized by the emergence of multiple fragments of mature bone in the dermis.…”
Section: Introductionmentioning
confidence: 99%