Multiple-micronutrient supplementation for women during pregnancy

Effect of multiple micronutrient supplementation during pregnancy on maternal and birth outcomes

“…These findings are comparable to the results of the systematic review of UNIMAPP trials [37] (pooled OR = 0.90; 95% CI: 0.82 – 0.99) based on 12 studies, which are also included in our analysis. These findings are however, different from our previous Cochrane review which was based on a limited set of studies [14] and reported a non-significant effect on SGA (RR = 1.04; 95% CI: 0.93 – 1.17). Our current data are also at variance with a recent meta-analysis by Shah et al [38] which analyzed results from only 5 RCTs and reported a statistically insignificant impact on SGA (RR = 0.89; 95% CI: 0.77 – 1.01).…”

“…These findings corroborates those from earlier reviews [14,36] which also revealed no significant benefit of multiple micronutrients over iron-folate. However, our review does indicate that multiple micronutrient administration is associated with a significant reduction in SGA births in comparison with iron-folate administration (9% and 12% reduction in the fixed and random effects models, respectively).…”

Effect of multiple micronutrient supplementation during pregnancy on maternal and birth outcomes

“…These findings are comparable to the results of the systematic review of UNIMAPP trials [37] (pooled OR = 0.90; 95% CI: 0.82 – 0.99) based on 12 studies, which are also included in our analysis. These findings are however, different from our previous Cochrane review which was based on a limited set of studies [14] and reported a non-significant effect on SGA (RR = 1.04; 95% CI: 0.93 – 1.17). Our current data are also at variance with a recent meta-analysis by Shah et al [38] which analyzed results from only 5 RCTs and reported a statistically insignificant impact on SGA (RR = 0.89; 95% CI: 0.77 – 1.01).…”

“…These findings corroborates those from earlier reviews [14,36] which also revealed no significant benefit of multiple micronutrients over iron-folate. However, our review does indicate that multiple micronutrient administration is associated with a significant reduction in SGA births in comparison with iron-folate administration (9% and 12% reduction in the fixed and random effects models, respectively).…”

Effect of Maternal Multiple Micronutrient vs Iron–Folic Acid Supplementation on Infant Mortality and Adverse Birth Outcomes in Rural Bangladesh

“…This size difference is consistent with a 53-g increment and RR of 0.86 for LBW obtained from systematic reviews of MM supplementation trials across low-income regions, including South Asia. 13,15,29 However, unlike findings from overviews, 13,25,26 we found little difference in the risk of infants born small for gestational age and thus attribute observed gains in size to longer gestation. Antenatal MM supplementation may have affected gestational and fetal nutrition through metabolic pathways other than those regulated by iron and folate.…”

“…13 However, trials have often not been designed or powered to detect differences in later infant mortality or multiple maternalfetal and infant outcomes. 25,26 Among those that have, our finding is not consistent with an 18% reduction in 3-month infant mortality after antenatal MM vs iron-folic acid supplementation in Indonesia 15 or a significant reduction in infant mortality to a year elsewhere in Bangladesh when MM supplementation was combined with food provision early (although not later) in pregnancy. 27 We observed, however, differences in risk of adverse birth outcomes.…”

Multiple Micronutrient Supplementation during Pregnancy in Low-Income Countries: A Meta-Analysis of Effects on Birth Size and Length of Gestation

“…The increase in birthweight and reduction in LBW and SGA births was consistent with the results of an earlier meta-analysis [9] and with other, more recent trials [29, 30]. There was no increase in other birth measurements.…”

Effect of multiple micronutrient supplementation during pregnancy on maternal and birth outcomes

“…These findings are comparable to the results of the systematic review of UNIMAPP trials [37] (pooled OR = 0.90; 95% CI: 0.82 – 0.99) based on 12 studies, which are also included in our analysis. These findings are however, different from our previous Cochrane review which was based on a limited set of studies [14] and reported a non-significant effect on SGA (RR = 1.04; 95% CI: 0.93 – 1.17). Our current data are also at variance with a recent meta-analysis by Shah et al [38] which analyzed results from only 5 RCTs and reported a statistically insignificant impact on SGA (RR = 0.89; 95% CI: 0.77 – 1.01).…”

“…These findings corroborates those from earlier reviews [14,36] which also revealed no significant benefit of multiple micronutrients over iron-folate. However, our review does indicate that multiple micronutrient administration is associated with a significant reduction in SGA births in comparison with iron-folate administration (9% and 12% reduction in the fixed and random effects models, respectively).…”

Effect of Maternal Multiple Micronutrient vs Iron–Folic Acid Supplementation on Infant Mortality and Adverse Birth Outcomes in Rural Bangladesh

“…This size difference is consistent with a 53-g increment and RR of 0.86 for LBW obtained from systematic reviews of MM supplementation trials across low-income regions, including South Asia. 13,15,29 However, unlike findings from overviews, 13,25,26 we found little difference in the risk of infants born small for gestational age and thus attribute observed gains in size to longer gestation. Antenatal MM supplementation may have affected gestational and fetal nutrition through metabolic pathways other than those regulated by iron and folate.…”

“…13 However, trials have often not been designed or powered to detect differences in later infant mortality or multiple maternalfetal and infant outcomes. 25,26 Among those that have, our finding is not consistent with an 18% reduction in 3-month infant mortality after antenatal MM vs iron-folic acid supplementation in Indonesia 15 or a significant reduction in infant mortality to a year elsewhere in Bangladesh when MM supplementation was combined with food provision early (although not later) in pregnancy. 27 We observed, however, differences in risk of adverse birth outcomes.…”

Multiple Micronutrient Supplementation during Pregnancy in Low-Income Countries: A Meta-Analysis of Effects on Birth Size and Length of Gestation

“…The increase in birthweight and reduction in LBW and SGA births was consistent with the results of an earlier meta-analysis [9] and with other, more recent trials [29, 30]. There was no increase in other birth measurements.…”

Effect of multiple micronutrient supplementation during pregnancy on maternal and birth outcomes

“…These findings are comparable to the results of the systematic review of UNIMAPP trials [37] (pooled OR = 0.90; 95% CI: 0.82 – 0.99) based on 12 studies, which are also included in our analysis. These findings are however, different from our previous Cochrane review which was based on a limited set of studies [14] and reported a non-significant effect on SGA (RR = 1.04; 95% CI: 0.93 – 1.17). Our current data are also at variance with a recent meta-analysis by Shah et al [38] which analyzed results from only 5 RCTs and reported a statistically insignificant impact on SGA (RR = 0.89; 95% CI: 0.77 – 1.01).…”

“…These findings corroborates those from earlier reviews [14,36] which also revealed no significant benefit of multiple micronutrients over iron-folate. However, our review does indicate that multiple micronutrient administration is associated with a significant reduction in SGA births in comparison with iron-folate administration (9% and 12% reduction in the fixed and random effects models, respectively).…”

Effect of Maternal Multiple Micronutrient vs Iron–Folic Acid Supplementation on Infant Mortality and Adverse Birth Outcomes in Rural Bangladesh

“…This size difference is consistent with a 53-g increment and RR of 0.86 for LBW obtained from systematic reviews of MM supplementation trials across low-income regions, including South Asia. 13,15,29 However, unlike findings from overviews, 13,25,26 we found little difference in the risk of infants born small for gestational age and thus attribute observed gains in size to longer gestation. Antenatal MM supplementation may have affected gestational and fetal nutrition through metabolic pathways other than those regulated by iron and folate.…”

“…13 However, trials have often not been designed or powered to detect differences in later infant mortality or multiple maternalfetal and infant outcomes. 25,26 Among those that have, our finding is not consistent with an 18% reduction in 3-month infant mortality after antenatal MM vs iron-folic acid supplementation in Indonesia 15 or a significant reduction in infant mortality to a year elsewhere in Bangladesh when MM supplementation was combined with food provision early (although not later) in pregnancy. 27 We observed, however, differences in risk of adverse birth outcomes.…”

Multiple Micronutrient Supplementation during Pregnancy in Low-Income Countries: A Meta-Analysis of Effects on Birth Size and Length of Gestation

“…The increase in birthweight and reduction in LBW and SGA births was consistent with the results of an earlier meta-analysis [9] and with other, more recent trials [29, 30]. There was no increase in other birth measurements.…”