Multiple Micronutrient Supplementation during Pregnancy in Low-Income Countries: A Meta-Analysis of Effects on Birth Size and Length of Gestation

Effect of prenatal multiple micronutrient supplementation compared with iron and folic acid supplementation on size at birth and subsequent growth through 24 mo of age: a systematic review and meta-analysis

“…We found that MMS resulted in higher HC from birth until 12 mo and a higher HCAZ from birth until 6 mo, which contrasts with previous systematic reviews that reported no overall effect on HC [ 50 , 55 ]. Fall et al [ 50 ] exclusively examined outcomes at birth, and only 10 studies contributed to the estimates of HC, compared to 12 in our analyses (including the largest trial [ 36 ]).…”

Effect of prenatal multiple micronutrient supplementation compared with iron and folic acid supplementation on size at birth and subsequent growth through 24 mo of age: a systematic review and meta-analysis

“…We found that MMS resulted in higher HC from birth until 12 mo and a higher HCAZ from birth until 6 mo, which contrasts with previous systematic reviews that reported no overall effect on HC [ 50 , 55 ]. Fall et al [ 50 ] exclusively examined outcomes at birth, and only 10 studies contributed to the estimates of HC, compared to 12 in our analyses (including the largest trial [ 36 ]).…”

Maternal antenatal multiple micronutrient supplementation for long-term health benefits in children: a systematic review and meta-analysis

“…Supplement composition was substantially different in this trial, which compared a supplement containing eight vitamins and no minerals with a 60 mg iron and 250 μg folic acid control [ 57 ]. Meta-analysis of the trials included in our review showed an increase in birthweight of 30.2 g (95 % CI, 14.1 to 46.3), which is similar in magnitude to that found in previous meta-analyses [ 11 , 61 – 63 ]. Similarly, three of the 11 trials included in the meta-analysis of neonatal mortality did not conduct follow-up studies.…”

Multivitamin Supplementation Is Associated with Greater Adequacy of Gestational Weight Gain among Pregnant Women in Tanzania

“…Our current results that multivitamin supplementation was associated with a greater GWG are consistent with the previous findings on birth outcomes in the same trial (14). Several metaanalyses have been conducted to summarize the effect of prenatal multiple micronutrient supplements on birth outcomes (11,12,(30)(31)(32), and it has been consistently concluded that the provision of multiple micronutrient supplements including iron and folic acid reduced the risks of low birthweight, compared to provision of iron and folic acid only, or provision of iron alone.…”

Effect of prenatal multiple micronutrient supplementation compared with iron and folic acid supplementation on size at birth and subsequent growth through 24 mo of age: a systematic review and meta-analysis

“…We found that MMS resulted in higher HC from birth until 12 mo and a higher HCAZ from birth until 6 mo, which contrasts with previous systematic reviews that reported no overall effect on HC [ 50 , 55 ]. Fall et al [ 50 ] exclusively examined outcomes at birth, and only 10 studies contributed to the estimates of HC, compared to 12 in our analyses (including the largest trial [ 36 ]).…”

Maternal antenatal multiple micronutrient supplementation for long-term health benefits in children: a systematic review and meta-analysis

“…Supplement composition was substantially different in this trial, which compared a supplement containing eight vitamins and no minerals with a 60 mg iron and 250 μg folic acid control [ 57 ]. Meta-analysis of the trials included in our review showed an increase in birthweight of 30.2 g (95 % CI, 14.1 to 46.3), which is similar in magnitude to that found in previous meta-analyses [ 11 , 61 – 63 ]. Similarly, three of the 11 trials included in the meta-analysis of neonatal mortality did not conduct follow-up studies.…”

Multivitamin Supplementation Is Associated with Greater Adequacy of Gestational Weight Gain among Pregnant Women in Tanzania

“…Our current results that multivitamin supplementation was associated with a greater GWG are consistent with the previous findings on birth outcomes in the same trial (14). Several metaanalyses have been conducted to summarize the effect of prenatal multiple micronutrient supplements on birth outcomes (11,12,(30)(31)(32), and it has been consistently concluded that the provision of multiple micronutrient supplements including iron and folic acid reduced the risks of low birthweight, compared to provision of iron and folic acid only, or provision of iron alone.…”

Effect of prenatal multiple micronutrient supplementation compared with iron and folic acid supplementation on size at birth and subsequent growth through 24 mo of age: a systematic review and meta-analysis

“…We found that MMS resulted in higher HC from birth until 12 mo and a higher HCAZ from birth until 6 mo, which contrasts with previous systematic reviews that reported no overall effect on HC [ 50 , 55 ]. Fall et al [ 50 ] exclusively examined outcomes at birth, and only 10 studies contributed to the estimates of HC, compared to 12 in our analyses (including the largest trial [ 36 ]).…”

Maternal antenatal multiple micronutrient supplementation for long-term health benefits in children: a systematic review and meta-analysis

“…Supplement composition was substantially different in this trial, which compared a supplement containing eight vitamins and no minerals with a 60 mg iron and 250 μg folic acid control [ 57 ]. Meta-analysis of the trials included in our review showed an increase in birthweight of 30.2 g (95 % CI, 14.1 to 46.3), which is similar in magnitude to that found in previous meta-analyses [ 11 , 61 – 63 ]. Similarly, three of the 11 trials included in the meta-analysis of neonatal mortality did not conduct follow-up studies.…”

Multivitamin Supplementation Is Associated with Greater Adequacy of Gestational Weight Gain among Pregnant Women in Tanzania

“…Our current results that multivitamin supplementation was associated with a greater GWG are consistent with the previous findings on birth outcomes in the same trial (14). Several metaanalyses have been conducted to summarize the effect of prenatal multiple micronutrient supplements on birth outcomes (11,12,(30)(31)(32), and it has been consistently concluded that the provision of multiple micronutrient supplements including iron and folic acid reduced the risks of low birthweight, compared to provision of iron and folic acid only, or provision of iron alone.…”