Multiple meningiomas of the central nervous system without the stigmata of neurofibromatosis. Clinical and therapeutic study

Abstract

Multiple meningiomas are relatively rare tumors without known neurofibromatosis. In this paper, such eight cases of multiple meningiomas as described by CUSHING and EISENHARDT are presented. Certain aspects of diagnosis and surgical management of this rare condition are discussed with particular emphasis on the importance of the distinction among multiple meningioma, meningiomatosis, or recurrences of these tumors. Fortunately, many of these patients tolerate multiple surgical interventions well, although the removal of these tumors in critical areas is a difficult problem. Thus, we think that it is important to examine and supervise all patients who have had a meningioma for a possible occurrence of a second meningioma.

Brain-sparing total meningeal radiation for a patient with widespread progressive meningiomas using helical intensity modulated radiation

“…Our patient differs from many of the cases of multiple meningiomas reported in the literature in that he had 10 lesions at the time of our treatment. A majority of patients in the published reports had 2-4 lesions [4,5].…”

“…Numerous reports have described the successful treatment of multiple meningiomas using surgical resection alone [4,5]. SRS is a more recent option for multiple meningioma patients in cases where surgery is inappropriate.…”

Multiple Meningiomas

“…A series of 8 cases of MM without neurofibromatosis have been described by Turgul et al [1]. Fortunately all his patients tolerated multiple surgical interventions well, although the removal of these tumours in critical areas may be difficult [1]. Thus it is important to examine and supervise all patients who have had a meningioma for a possible occurrence of a second meningioma.…”

“…MM not associated with neurofibromatosis are uncommon tumours [1]. Most cases present with chronic headache or complex partial seizures [2].…”

Multiple intracranial meningiomas: diagnosis, biological behavior and treatment

“…Meningiomas are tumors originated from arachnoidal cells present in the villi, in the granulations, in the stroma of the perivascular spaces and in the choroid plexus; corresponding to 13 to 20% of all intracranial tumors [1][2][3] . Multiple intracranial meningiomas (MIM), when not associated with neurofibromatosis, are a rare event, which corresponding to 2.3 to 8.9% of all intracranial meningiomas [4][5][6][7][8][9][10][11] . The multiple intracranial meningiomas terminology should be used only when two or more meningiomas occur either simultaneously or sequentially in different locations.…”