Multiple Lipoidal Histiocytomas With Regression

Robinson, Harry M.

doi:10.1001/archderm.1963.01590230168023

Cited by 24 publications

(7 citation statements)

References 9 publications

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“…Association with non-insulin-dependant diabetes mellitus (23% of AXG cases versus 5% in the general population) appears significant, whereas the incidence of hypercholesterolemia and hypertriglyceridemia is equivalent in AXG patients and in the general population [12]. Spontaneous regression was observed in 54% of the cases with a median duration in regressive cases of 22 months (mean duration of 44 months, extremes: 9/180 months); the difference between mean and median duration is explained by the exceptionally long evolution of 1 case [13]. Among the 6 cases for which no regression was observed, 4 were not followed up for 22 months; therefore, we cannot exclude the possibility of a later clearance of the lesions.…”

Section: Discussionmentioning

confidence: 99%

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Multiple Adult Xanthogranuloma: Case Report and Literature Review

et al. 2006

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Background: Non-Langerhans cell histiocytoses form a heterogeneous group defined by the proliferation of cells with macrophage characteristics. Diagnosis is easy in typical cases but becomes more complex in unusual forms. Case Report: We report the case of a 53-year-old patient who presented multiple brown-to-yellowish papules and nodules of the trunk, neck, and head evolving for 6 months. No visceral involvement was found. Histopathological examination revealed histiocytic proliferation with features of secondary xanthomization with the presence of giant foamy multinucleated Touton cells. One year later, all lesions cleared spontaneously. Based on the clinical presentation and evolution and on the immunohistologic data, we retain the diagnosis of adult xanthogranuloma (AXG) in a diffuse shape. Discussion: Multiple AXG is a rare entity (15 cases reported since 1963) with a stereotypic presentation. It is important to recognize because of its good prognosis and the absence of visceral involvement therefore requiring no investigations or aggressive treatments. This case is interesting because of the complete and spontaneous healing of all the lesions within 20 months.

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Section: Discussionmentioning

confidence: 99%

“…In MJXG, visceral lesions are not rare and account for 38% of the cases, whereas such lesions seem to be rare in MAXG. The evolutive pattern appears similar, with a rather higher proportion towards spontaneous clearance in MJXG (83% in 3–6 years) [3, 4, 13, 17]. …”

Section: Discussionmentioning

confidence: 99%

Multiple Adult Xanthogranuloma: Case Report and Literature Review

et al. 2006

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“…''Progressive nodular histiocytosis'' is the name suggested in 1985 by one of us 30 to encompass several cases reported in the literature with similar clinical and histopathologic features, [31][32][33][34] including the first one described as ''progressive nodular histiocytoma'' by Taunton …”

Section: Progressive Nodular Histiocytosis Definitionmentioning

confidence: 99%

“…Clinically, the disease is characterized by the progressive appearance of hundreds of lesions of two different types, namely superficial papules and deep nodules [31][32][33][34][35][36][37][38][39][40][41][42][43] (Fig 3, A).…”

Section: Clinical Findingsmentioning

confidence: 99%

“…Spontaneous regression of lesions has only occasionally been reported. 31,33,36 PNH has been reported in association with systemic disorders in two patients only: one 38 had chronic myeloid leukemia, hypothyroidism, and purine and lipoprotein metabolic changes, the other 42 was a child with precocious puberty, growth hormone deficiency, and a hypothalamic tumor.…”

Section: Course and Prognosismentioning

confidence: 99%

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Unusual variants of non-Langerhans cell histiocytoses

Caputo¹,

Marzano²,

Passoni³

et al. 2007

Journal of the American Academy of Dermatology

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Histiocytic syndromes represent a large, heterogeneous group of diseases resulting from proliferation of histiocytes. In addition to the classic variants, the subset of non-Langerhans cell histiocytoses comprises rare entities that have more recently been described. These last include both forms that affect only the skin or the skin and mucous membranes, and usually show a benign clinical behavior, and forms involving also internal organs, which may follow an aggressive course. The goal of this review is to outline the clinical, histologic, and ultrastructural features and the course, prognosis, and management of these unusual histiocytic syndromes.

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